ID   FLIPR_STAAS             Reviewed;         132 AA.
AC   Q6GA59;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=FPRL1 inhibitory protein;
DE            Short=FLIPr;
DE   Flags: Precursor;
GN   Name=flr; OrderedLocusNames=SAS1089;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: May be involved in countering the first line of host defense
CC       mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding
CC       directly to host FPRL1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG42864.1; -; Genomic_DNA.
DR   RefSeq; WP_000739582.1; NC_002953.3.
DR   AlphaFoldDB; Q6GA59; -.
DR   SMR; Q6GA59; -.
DR   KEGG; sas:SAS1089; -.
DR   HOGENOM; CLU_157996_0_0_9; -.
DR   OMA; KDDERAT; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.20.390; -; 1.
DR   InterPro; IPR023256; FLIPR.
DR   InterPro; IPR038529; FLIPR/CHIP_sf.
DR   InterPro; IPR023253; FLIPR/CHIPS.
DR   Pfam; PF16104; FPRL1_inhibitor; 1.
DR   PRINTS; PR02037; FLIPR.
DR   PRINTS; PR02035; FLIPRCHIPS.
PE   3: Inferred from homology;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..132
FT                   /note="FPRL1 inhibitory protein"
FT                   /id="PRO_0000286683"
SQ   SEQUENCE   132 AA;  14937 MW;  4448B4F6CB6102B6 CRC64;
     MKKNITKVII ASTVIATGLL TQTNDAKAFF SYEWKGLEIA KNLADQAKKD DERADKLIKE
     ADEKNEHYKG KTVEDLYVIA KKMGKGNTIA VVKIKDGGKN GYYTFDITRP LEEHRKNIPV
     VKNGEIDSIT WY