ID   FLIPR_STAAW             Reviewed;         132 AA.
AC   Q8NX51;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=FPRL1 inhibitory protein;
DE            Short=FLIPr;
DE   Flags: Precursor;
GN   Name=flr; OrderedLocusNames=MW1038;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: May be involved in countering the first line of host defense
CC       mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding
CC       directly to host FPRL1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000033; BAB94903.1; -; Genomic_DNA.
DR   RefSeq; WP_000739582.1; NC_003923.1.
DR   AlphaFoldDB; Q8NX51; -.
DR   SMR; Q8NX51; -.
DR   EnsemblBacteria; BAB94903; BAB94903; BAB94903.
DR   KEGG; sam:MW1038; -.
DR   HOGENOM; CLU_157996_0_0_9; -.
DR   OMA; KDDERAT; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.20.390; -; 1.
DR   InterPro; IPR023256; FLIPR.
DR   InterPro; IPR038529; FLIPR/CHIP_sf.
DR   InterPro; IPR023253; FLIPR/CHIPS.
DR   Pfam; PF16104; FPRL1_inhibitor; 1.
DR   PRINTS; PR02037; FLIPR.
DR   PRINTS; PR02035; FLIPRCHIPS.
PE   3: Inferred from homology;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..132
FT                   /note="FPRL1 inhibitory protein"
FT                   /id="PRO_0000286685"
SQ   SEQUENCE   132 AA;  14937 MW;  4448B4F6CB6102B6 CRC64;
     MKKNITKVII ASTVIATGLL TQTNDAKAFF SYEWKGLEIA KNLADQAKKD DERADKLIKE
     ADEKNEHYKG KTVEDLYVIA KKMGKGNTIA VVKIKDGGKN GYYTFDITRP LEEHRKNIPV
     VKNGEIDSIT WY