FLIP_ECOLI
ID FLIP_ECOLI Reviewed; 245 AA.
AC P0AC05; P33133;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Flagellar biosynthetic protein FliP;
DE Flags: Precursor;
GN Name=fliP; Synonyms=flaR; OrderedLocusNames=b1948, JW1932;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=8282695; DOI=10.1128/jb.176.1.189-197.1994;
RA Malakooti J., Ely B., Matsumura P.;
RT "Molecular characterization, nucleotide sequence, and expression of the
RT fliO, fliP, fliQ, and fliR genes of Escherichia coli.";
RL J. Bacteriol. 176:189-197(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Plays a role in the flagellum-specific transport system.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}. Bacterial flagellum basal body
CC {ECO:0000269|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the FliP/MopC/SpaP family. {ECO:0000305}.
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DR EMBL; L22182; AAC36859.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15773.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75015.1; -; Genomic_DNA.
DR PIR; B36869; B36869.
DR RefSeq; NP_416458.1; NC_000913.3.
DR RefSeq; WP_001253441.1; NZ_STEB01000050.1.
DR AlphaFoldDB; P0AC05; -.
DR SMR; P0AC05; -.
DR BioGRID; 4261044; 438.
DR ComplexPortal; CPX-5885; Flagellar export complex.
DR STRING; 511145.b1948; -.
DR PaxDb; P0AC05; -.
DR PRIDE; P0AC05; -.
DR EnsemblBacteria; AAC75015; AAC75015; b1948.
DR EnsemblBacteria; BAA15773; BAA15773; BAA15773.
DR GeneID; 66674162; -.
DR GeneID; 946462; -.
DR KEGG; ecj:JW1932; -.
DR KEGG; eco:b1948; -.
DR PATRIC; fig|1411691.4.peg.303; -.
DR EchoBASE; EB1918; -.
DR eggNOG; COG1338; Bacteria.
DR HOGENOM; CLU_042028_0_1_6; -.
DR InParanoid; P0AC05; -.
DR OMA; MPPNQIL; -.
DR PhylomeDB; P0AC05; -.
DR BioCyc; EcoCyc:EG11975-MON; -.
DR PRO; PR:P0AC05; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009288; C:bacterial-type flagellum; IC:ComplexPortal.
DR GO; GO:0120102; C:bacterial-type flagellum secretion apparatus; IC:ComplexPortal.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0030257; C:type III protein secretion system complex; IC:ComplexPortal.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IC:ComplexPortal.
DR GO; GO:0006935; P:chemotaxis; IC:ComplexPortal.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IC:ComplexPortal.
DR InterPro; IPR005837; FliP.
DR InterPro; IPR005838; T3SS_IM_P.
DR PANTHER; PTHR30587; PTHR30587; 1.
DR PANTHER; PTHR30587:SF0; PTHR30587:SF0; 1.
DR Pfam; PF00813; FliP; 1.
DR PRINTS; PR00951; FLGBIOSNFLIP.
DR PRINTS; PR01302; TYPE3IMPPROT.
DR TIGRFAMs; TIGR01103; fliP; 1.
DR PROSITE; PS01060; FLIP_1; 1.
DR PROSITE; PS01061; FLIP_2; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum; Bacterial flagellum biogenesis;
KW Bacterial flagellum protein export; Cell inner membrane; Cell membrane;
KW Membrane; Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..245
FT /note="Flagellar biosynthetic protein FliP"
FT /id="PRO_0000009535"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 245 AA; 26928 MW; C8E84B7B10FD1D26 CRC64;
MRRLLSVAPV LLWLITPLAF AQLPGITSQP LPGGGQSWSL PVQTLVFITS LTFIPAILLM
MTSFTRIIIV FGLLRNALGT PSAPPNQVLL GLALFLTFFI MSPVIDKIYV DAYQPFSEEK
ISMQEALEKG AQPLREFMLR QTREADLGLF ARLANTGPLQ GPEAVPMRIL LPAYVTSELK
TAFQIGFTIF IPFLIIDLVI ASVLMALGMM MVPPATIALP FKLMLFVLVD GWQLLVGSLA
QSFYS
