ID   FLIR_TREPA              Reviewed;         265 AA.
AC   P74932;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Flagellar biosynthetic protein FliR;
GN   Name=fliR; OrderedLocusNames=TP_0716;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=8529894; DOI=10.1016/0378-1119(95)00583-x;
RA   Hardham J.M., Frye J.G., Stamm L.V.;
RT   "Identification and sequences of the Treponema pallidum fliM', fliY, fliP,
RT   fliQ, fliR and flhB' genes.";
RL   Gene 166:57-64(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Role in flagellar biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Bacterial flagellum basal body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FliR/MopE/SpaR family. {ECO:0000305}.
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DR   EMBL; U36839; AAB00548.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65682.1; -; Genomic_DNA.
DR   PIR; JC4509; JC4509.
DR   RefSeq; WP_010882161.1; NC_021490.2.
DR   AlphaFoldDB; P74932; -.
DR   SMR; P74932; -.
DR   IntAct; P74932; 6.
DR   STRING; 243276.TPANIC_0716; -.
DR   EnsemblBacteria; AAC65682; AAC65682; TP_0716.
DR   GeneID; 57879241; -.
DR   KEGG; tpa:TP_0716; -.
DR   eggNOG; COG1684; Bacteria.
DR   HOGENOM; CLU_063626_2_0_12; -.
DR   OMA; APQFNIF; -.
DR   OrthoDB; 1942709at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0006605; P:protein targeting; IEA:InterPro.
DR   InterPro; IPR006303; FliR.
DR   InterPro; IPR002010; T3SS_IM_R.
DR   PANTHER; PTHR30065; PTHR30065; 1.
DR   Pfam; PF01311; Bac_export_1; 1.
DR   PRINTS; PR00953; TYPE3IMRPROT.
DR   TIGRFAMs; TIGR01400; fliR; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..265
FT                   /note="Flagellar biosynthetic protein FliR"
FT                   /id="PRO_0000192058"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   265 AA;  29313 MW;  A9BFA16FEE365C09 CRC64;
     MERSFDALFS QASLFFLAAV RVFALMFTVP LLSVRSVSRV VRVALAGLIA FLVLPLAYPA
     PMQVREFSAY YVLLLLGEGL LGILTGFFIS VIFTTFSAAG QFFSYQMGFG TSEMYDTFAQ
     IENPLMGQFL NFVAMLVFLQ IKGFQILFLG GVLRSFQAVN CFVFLRKQEA LLLFFTKALS
     ALFLHAMTIA LPIMGALLLI HVSMGLLTKA APQMNLLSEG LPLTIVVTFV LLSVILPYMI
     NLFVSILFGG FEMFEQLLVK LGKAL