ID   FLIS_CAMJ8              Reviewed;         128 AA.
AC   P0DPD3;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 1.
DT   03-AUG-2022, entry version 13.
DE   RecName: Full=Flagellar secretion chaperone FliS;
GN   Name=fliS; OrderedLocusNames=C8J_0510;
OS   Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC
OS   11828).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=407148;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=81116 / NCTC 11828;
RX   PubMed=17873037; DOI=10.1128/jb.01404-07;
RA   Pearson B.M., Gaskin D.J.H., Segers R.P.A.M., Wells J.M., Nuijten P.J.M.,
RA   van Vliet A.H.M.;
RT   "The complete genome sequence of Campylobacter jejuni strain 81116
RT   (NCTC11828).";
RL   J. Bacteriol. 189:8402-8403(2007).
RN   [2]
RP   FUNCTION, INTERACTION WITH FLAGELLINS FLAA; FLAB AND FLAC, SUBUNIT, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=81116 / NCTC 11828;
RX   PubMed=28659885; DOI=10.3389/fmicb.2017.01060;
RA   Radomska K.A., Woesten M.M.S.M., Ordonez S.R., Wagenaar J.A.,
RA   van Putten J.P.M.;
RT   "Importance of Campylobacter jejuni FliS and FliW in flagella biogenesis
RT   and flagellin secretion.";
RL   Front. Microbiol. 8:1060-1060(2017).
CC   -!- FUNCTION: Required for flagellar assembly and thus bacterial motility
CC       (PubMed:28659885). {ECO:0000269|PubMed:28659885}.
CC   -!- SUBUNIT: Interacts with flagellins FlaA, FlaB and FlaC; preferentially
CC       binds glycosylated FlaA over non-glycosylated protein
CC       (PubMed:28659885). Requires the 10 last residues of FlaA for binding
CC       (PubMed:28659885). May form a 3-way complex of flagellin, FliS and FliW
CC       simultaneously in which FliS and FliW do not directly interact (By
CC       similarity). {ECO:0000250|UniProtKB:P39739,
CC       ECO:0000269|PubMed:28659885}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Cells are non-motile, flagellar filaments are
CC       severely truncated (PubMed:28659885). Strongly reduced levels of
CC       secreted flagellins FlaA, FlaB and FlaC (PubMed:28659885).
CC       {ECO:0000269|PubMed:28659885}.
CC   -!- SIMILARITY: Belongs to the FliS family. {ECO:0000305}.
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DR   EMBL; CP000814; ABV52109.1; -; Genomic_DNA.
DR   RefSeq; WP_002854990.1; NC_009839.1.
DR   AlphaFoldDB; P0DPD3; -.
DR   SMR; P0DPD3; -.
DR   KEGG; cju:C8J_0510; -.
DR   HOGENOM; CLU_080373_3_1_7; -.
DR   OMA; EFRDTWK; -.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   CDD; cd16098; FliS; 1.
DR   InterPro; IPR003713; FliS.
DR   InterPro; IPR036584; FliS_sf.
DR   PANTHER; PTHR34773; PTHR34773; 1.
DR   Pfam; PF02561; FliS; 1.
DR   PIRSF; PIRSF039090; Flis; 1.
DR   SUPFAM; SSF101116; SSF101116; 1.
DR   TIGRFAMs; TIGR00208; fliS; 1.
PE   1: Evidence at protein level;
KW   Bacterial flagellum biogenesis; Chaperone; Cytoplasm.
FT   CHAIN           1..128
FT                   /note="Flagellar secretion chaperone FliS"
FT                   /id="PRO_0000442733"
SQ   SEQUENCE   128 AA;  14779 MW;  99241F45546437AA CRC64;
     MQNNLAYNAY SQNQAGIESP QKLIEMLYEG ILRFCARAKV AIRNEDIEQR VYFVKRTTAI
     FIELINTLDY EKGGEVAHYL SGLYTREIQL LSLANLENNE DRINEVINVT KGLLEAWREV
     HNNETVAQ