FLIW2_HELPY
ID FLIW2_HELPY Reviewed; 129 AA.
AC O25929;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Flagellar assembly factor FliW 2 {ECO:0000255|HAMAP-Rule:MF_01185};
GN Name=fliW2 {ECO:0000255|HAMAP-Rule:MF_01185}; OrderedLocusNames=HP_1377;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP BINDING TO FLAGELLIN.
RX PubMed=11196647; DOI=10.1038/35051615;
RA Rain J.-C., Selig L., De Reuse H., Battaglia V., Reverdy C., Simon S.,
RA Lenzen G., Petel F., Wojcik J., Schaechter V., Chemama Y., Labigne A.,
RA Legrain P.;
RT "The protein-protein interaction map of Helicobacter pylori.";
RL Nature 409:211-215(2001).
CC -!- FUNCTION: Acts as an anti-CsrA protein, binds CsrA and prevents it from
CC repressing translation of its target genes, one of which is flagellin.
CC Binds to flagellin and participates in the assembly of the flagellum.
CC {ECO:0000255|HAMAP-Rule:MF_01185}.
CC -!- SUBUNIT: Interacts with translational regulator CsrA and flagellin(s).
CC {ECO:0000255|HAMAP-Rule:MF_01185, ECO:0000269|PubMed:11196647}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01185}.
CC -!- SIMILARITY: Belongs to the FliW family. {ECO:0000255|HAMAP-
CC Rule:MF_01185, ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD08427.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE000511; AAD08427.1; ALT_INIT; Genomic_DNA.
DR PIR; A64692; A64692.
DR RefSeq; NP_208168.2; NC_000915.1.
DR RefSeq; WP_001862609.1; NC_018939.1.
DR AlphaFoldDB; O25929; -.
DR SMR; O25929; -.
DR DIP; DIP-3274N; -.
DR IntAct; O25929; 3.
DR MINT; O25929; -.
DR STRING; 85962.C694_07105; -.
DR PaxDb; O25929; -.
DR DNASU; 900306; -.
DR EnsemblBacteria; AAD08427; AAD08427; HP_1377.
DR KEGG; hpy:HP_1377; -.
DR PATRIC; fig|85962.47.peg.1474; -.
DR eggNOG; COG1699; Bacteria.
DR OMA; TIHKMHL; -.
DR PhylomeDB; O25929; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 2.30.290.10; -; 1.
DR HAMAP; MF_01185; FliW; 1.
DR InterPro; IPR003775; Flagellar_assembly_factor_FliW.
DR InterPro; IPR024046; Flagellar_assmbl_FliW_dom_sf.
DR PANTHER; PTHR39190; PTHR39190; 1.
DR Pfam; PF02623; FliW; 1.
DR SUPFAM; SSF141457; SSF141457; 1.
PE 1: Evidence at protein level;
KW Bacterial flagellum biogenesis; Chaperone; Cytoplasm; Reference proteome;
KW Translation regulation.
FT CHAIN 1..129
FT /note="Flagellar assembly factor FliW 2"
FT /id="PRO_0000273000"
SQ SEQUENCE 129 AA; 14862 MW; EFB0B7364D52B65A CRC64;
MIFDVKAPIL GFETIHKMRL QKIDEIFLRL NSTEENSVVS FTLVNPFALR KYEFEVPTPL
KILLELEGAK SVLVANIMVV QTPIELSTVN YLAPLIFNLD KQLMGQVVLD SNKYPHYHLR
ENILSHTHE