FLIW_CLOD6
ID FLIW_CLOD6 Reviewed; 130 AA.
AC Q18CX4;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Flagellar assembly factor FliW {ECO:0000255|HAMAP-Rule:MF_01185};
GN Name=fliW {ECO:0000255|HAMAP-Rule:MF_01185}; OrderedLocusNames=CD630_02330;
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630;
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
CC -!- FUNCTION: Acts as an anti-CsrA protein, binds CsrA and prevents it from
CC repressing translation of its target genes, one of which is flagellin.
CC Binds to flagellin and participates in the assembly of the flagellum.
CC {ECO:0000255|HAMAP-Rule:MF_01185}.
CC -!- SUBUNIT: Interacts with translational regulator CsrA and flagellin(s).
CC {ECO:0000255|HAMAP-Rule:MF_01185}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01185}.
CC -!- SIMILARITY: Belongs to the FliW family. {ECO:0000255|HAMAP-
CC Rule:MF_01185}.
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DR EMBL; AM180355; CAJ67054.1; -; Genomic_DNA.
DR RefSeq; WP_011860685.1; NZ_CP010905.2.
DR RefSeq; YP_001086701.1; NC_009089.1.
DR AlphaFoldDB; Q18CX4; -.
DR SMR; Q18CX4; -.
DR STRING; 272563.CD630_02330; -.
DR EnsemblBacteria; CAJ67054; CAJ67054; CD630_02330.
DR KEGG; cdf:CD630_02330; -.
DR KEGG; pdc:CDIF630_00355; -.
DR PATRIC; fig|272563.120.peg.249; -.
DR eggNOG; COG1699; Bacteria.
DR OMA; TIHKMHL; -.
DR PhylomeDB; Q18CX4; -.
DR BioCyc; PDIF272563:G12WB-336-MON; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 2.30.290.10; -; 1.
DR HAMAP; MF_01185; FliW; 1.
DR InterPro; IPR003775; Flagellar_assembly_factor_FliW.
DR InterPro; IPR024046; Flagellar_assmbl_FliW_dom_sf.
DR PANTHER; PTHR39190; PTHR39190; 1.
DR Pfam; PF02623; FliW; 1.
DR SUPFAM; SSF141457; SSF141457; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis; Chaperone; Cytoplasm; Reference proteome;
KW Translation regulation.
FT CHAIN 1..130
FT /note="Flagellar assembly factor FliW"
FT /id="PRO_0000272980"
SQ SEQUENCE 130 AA; 14891 MW; 0061440B4A4E699E CRC64;
MMKITLKKGI LGFENLKEYE LLDIENEDIL KEFNSTEEDC IGFIVVSPFE IIKEYEIVLN
QETIEKLEVK SPNDIMLLNI ITVGQTLEES TVNMKAPIVI NVRNNCGMQI ILQDEEYSIW
HPLLRGDGGC