ID   AL14E_BOVIN             Reviewed;         260 AA.
AC   Q5EA92; Q2KIN9;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=ARL14 effector protein;
DE   AltName: Full=ARF7 effector protein;
GN   Name=ARL14EP; Synonyms=ARF7EP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Through its interaction with ARL14 and MYO1E, may connect MHC
CC       class II-containing cytoplasmic vesicles to the actin network and hence
CC       controls the movement of these vesicles along the actin cytoskeleton in
CC       dendritic cells. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ARL14 and MYO1E. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BT020677; AAX08694.1; -; mRNA.
DR   EMBL; BC112569; AAI12570.1; -; mRNA.
DR   RefSeq; NP_001026931.2; NM_001031761.3.
DR   RefSeq; XP_005216337.1; XM_005216280.3.
DR   AlphaFoldDB; Q5EA92; -.
DR   STRING; 9913.ENSBTAP00000042134; -.
DR   PaxDb; Q5EA92; -.
DR   PRIDE; Q5EA92; -.
DR   Ensembl; ENSBTAT00000044657; ENSBTAP00000042134; ENSBTAG00000012417.
DR   Ensembl; ENSBTAT00000081767; ENSBTAP00000072039; ENSBTAG00000012417.
DR   GeneID; 523894; -.
DR   KEGG; bta:523894; -.
DR   CTD; 120534; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012417; -.
DR   VGNC; VGNC:26140; ARL14EP.
DR   eggNOG; KOG4850; Eukaryota.
DR   GeneTree; ENSGT00940000156586; -.
DR   HOGENOM; CLU_093502_0_0_1; -.
DR   InParanoid; Q5EA92; -.
DR   OMA; CMQIING; -.
DR   OrthoDB; 1056242at2759; -.
DR   TreeFam; TF333216; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000012417; Expressed in spermatid and 104 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   InterPro; IPR029264; ARF7EP_C.
DR   InterPro; IPR026515; ARL14EP.
DR   PANTHER; PTHR46536; PTHR46536; 1.
DR   Pfam; PF14949; ARF7EP_C; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Isopeptide bond; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..260
FT                   /note="ARL14 effector protein"
FT                   /id="PRO_0000251891"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N8R7"
FT   MOD_RES         183
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N8R7"
FT   CROSSLNK        177
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N8R7"
FT   CONFLICT        254
FT                   /note="I -> N (in Ref. 2; AAI12570)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   260 AA;  29209 MW;  91FB05362E1F547D CRC64;
     MMDPCSVGVQ LRTTNECHKT YYTRHTGFKT LQELSSNDML LLQLRTGMTL SGNNTICFHH
     AKVYIDRFED LQKSCCDPFN IHKKLAKKNL HVIDLDDATF LSAKFGRQLV PGWKLCPKCT
     QIINGSVDVD SEDRQKRKPD SDGRTAKALR SLQFANPGKQ TEFAPETGKR EKRRLTKNAT
     AGSDRQVIPA KSKVYDSQGL LIFSGMDLCD CLDEDCLGCF YACPACGSTK CGAECRCDRK
     WLYEQIEIEG GEIIHNKHAG