ID   AL14E_RAT               Reviewed;         276 AA.
AC   Q5FVK8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=ARL14 effector protein;
DE   AltName: Full=ARF7 effector protein;
GN   Name=Arl14ep; Synonyms=Arf7ep;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Through its interaction with ARL14 and MYO1E, may connect MHC
CC       class II-containing cytoplasmic vesicles to the actin network and hence
CC       controls the movement of these vesicles along the actin cytoskeleton in
CC       dendritic cells. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ARL14 and MYO1E. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BC089920; AAH89920.1; -; mRNA.
DR   RefSeq; NP_001014067.1; NM_001014045.1.
DR   RefSeq; XP_008760314.1; XM_008762092.2.
DR   AlphaFoldDB; Q5FVK8; -.
DR   STRING; 10116.ENSRNOP00000006481; -.
DR   iPTMnet; Q5FVK8; -.
DR   PhosphoSitePlus; Q5FVK8; -.
DR   PaxDb; Q5FVK8; -.
DR   Ensembl; ENSRNOT00000006481; ENSRNOP00000006481; ENSRNOG00000004891.
DR   GeneID; 311279; -.
DR   KEGG; rno:311279; -.
DR   UCSC; RGD:1311463; rat.
DR   CTD; 120534; -.
DR   RGD; 1311463; Arl14ep.
DR   eggNOG; KOG4850; Eukaryota.
DR   GeneTree; ENSGT00940000156586; -.
DR   HOGENOM; CLU_093502_0_0_1; -.
DR   InParanoid; Q5FVK8; -.
DR   OMA; CMQIING; -.
DR   OrthoDB; 1056242at2759; -.
DR   PhylomeDB; Q5FVK8; -.
DR   TreeFam; TF333216; -.
DR   PRO; PR:Q5FVK8; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000004891; Expressed in cerebellum and 19 other tissues.
DR   Genevisible; Q5FVK8; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   InterPro; IPR029264; ARF7EP_C.
DR   InterPro; IPR026515; ARL14EP.
DR   PANTHER; PTHR46536; PTHR46536; 1.
DR   Pfam; PF14949; ARF7EP_C; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Isopeptide bond; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..276
FT                   /note="ARL14 effector protein"
FT                   /id="PRO_0000251894"
FT   REGION          159..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         182
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N8R7"
FT   MOD_RES         266
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   CROSSLNK        176
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N8R7"
SQ   SEQUENCE   276 AA;  31112 MW;  A79E194DF5DED2AA CRC64;
     MDPCSVGVQL RTTHDCHKTF YTRHTGFKTL KELSSNDMLL LQLRTGMTLS GNNTICLHHV
     KIYIERFEEL QKSCCDPFNI HKKLAKKNLH VIDLDDATFL SAKFGRQLVP GWKLCPKCTQ
     IINGSVDVDS DDRQRRKPES DGRTAKALRS LQFTNPGKQT EFAPESGKRE KRKLTKNASA
     SSDRQIIPAK SKVYDSQGLL IFSGMDLCDC LDEDCLGCFY ACPTCGSTKC GAECRCDRKW
     LYEQIEIEGG EIIHNKHAGK AYGLLSPCHP YDILQK