FLIZ_ECOLI
ID FLIZ_ECOLI Reviewed; 183 AA.
AC P52627; P76317;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Regulator of sigma S factor FliZ;
GN Name=fliZ; Synonyms=yedH; OrderedLocusNames=b1921, JW1906;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / RP437;
RX PubMed=8550423; DOI=10.1128/jb.178.1.24-34.1996;
RA Mytelka D.S., Chamberlin M.J.;
RT "Escherichia coli fliAZY operon.";
RL J. Bacteriol. 178:24-34(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
RC STRAIN=K12;
RX PubMed=7590326; DOI=10.1016/0378-1119(95)00480-t;
RA Liu X., Matsumura P.;
RT "An alternative sigma factor controls transcription of flagellar class-III
RT operons in Escherichia coli: gene sequence, overproduction, purification
RT and characterization.";
RL Gene 164:81-84(1995).
RN [6]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574, and
RC K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=18765794; DOI=10.1101/gad.475808;
RA Pesavento C., Becker G., Sommerfeldt N., Possling A., Tschowri N.,
RA Mehlis A., Hengge R.;
RT "Inverse regulatory coordination of motility and curli-mediated adhesion in
RT Escherichia coli.";
RL Genes Dev. 22:2434-2446(2008).
CC -!- FUNCTION: During the post-exponential growth phase transiently
CC interferes with RpoS (sigma S) activity without affecting expression of
CC RpoS itself. It is probably not an anti-sigma factor as its
CC overexpression is detrimental in rapidly growing cells where there is
CC almost no sigma S factor. There is a strong overlap between Crl-
CC activated genes and FliZ-down-regulated genes. FliZ acts as a timing
CC device for expression of the genes for the adhesive curli fimbriae by
CC indirectly decreasing expression of the curli regulator CsgD.
CC {ECO:0000269|PubMed:18765794}.
CC -!- INDUCTION: Induced in early post-exponential phase, its expression
CC decreases again at OD578 2-2.5. {ECO:0000269|PubMed:18765794}.
CC -!- DISRUPTION PHENOTYPE: Not required for motility, disruption leads to
CC derepression of the adhesive curli fimbriae genes.
CC {ECO:0000269|PubMed:18765794}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC43544.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U18539; AAC43544.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC74988.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA15741.1; -; Genomic_DNA.
DR EMBL; L36677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; F64955; F64955.
DR RefSeq; NP_416431.2; NC_000913.3.
DR RefSeq; WP_001350518.1; NZ_LN832404.1.
DR AlphaFoldDB; P52627; -.
DR BioGRID; 4263070; 103.
DR BioGRID; 851174; 1.
DR IntAct; P52627; 7.
DR STRING; 511145.b1921; -.
DR PaxDb; P52627; -.
DR PRIDE; P52627; -.
DR EnsemblBacteria; AAC74988; AAC74988; b1921.
DR EnsemblBacteria; BAA15741; BAA15741; BAA15741.
DR GeneID; 946833; -.
DR KEGG; ecj:JW1906; -.
DR KEGG; eco:b1921; -.
DR PATRIC; fig|1411691.4.peg.328; -.
DR EchoBASE; EB1331; -.
DR eggNOG; ENOG502Z9YQ; Bacteria.
DR HOGENOM; CLU_132109_0_0_6; -.
DR OMA; LHCKEQS; -.
DR PhylomeDB; P52627; -.
DR BioCyc; EcoCyc:EG11356-MON; -.
DR PRO; PR:P52627; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0016989; F:sigma factor antagonist activity; IMP:EcoCyc.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:1902021; P:regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc.
DR InterPro; IPR022523; Flagellar_regulator_FliZ.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR TIGRFAMs; TIGR03823; FliZ; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..183
FT /note="Regulator of sigma S factor FliZ"
FT /id="PRO_0000087288"
SQ SEQUENCE 183 AA; 21658 MW; CBFF9A95BDDC4711 CRC64;
MMVQHLKRRP LSRYLKDFKH SQTHCAHCRK LLDRITLVRD GKIVNKIEIS RLDTLLDENG
WQTEQKSWAA LCRFCGDLHC KTQSDFFDII GFKQFLFEQT EMSPGTVREY VVRLRRLGNH
LHEQNISLDQ LQDGFLDEIL APWLPTTSTN NYRIALRKYQ HYQRQTCTRL VQKSSSLPSS
DIY
