AL15_ASPFU
ID AL15_ASPFU Reviewed; 152 AA.
AC O60022; P82261; Q4X0Q8;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Allergen Asp f 15;
DE AltName: Full=Allergen Asp f 13;
DE AltName: Allergen=Asp f 15;
DE Flags: Precursor;
GN ORFNames=AFUA_2G12630;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ATCC 42202 / AF-102 / Ag 507;
RA Hemmann S., Blaser K., Crameri R.;
RT "A novel allergen of Aspergillus fumigatus (rAsp f 13) shares homology with
RT a 19 kD antigen of Coccidioides immitis.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [3]
RP PROTEIN SEQUENCE OF 29-49.
RC STRAIN=AF-285 / Indian isolate;
RA Sarma P.U., Gupta T.M., Fairwell T.;
RL Submitted (DEC-1999) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALLERGEN: Causes an allergic reaction in human.
CC -!- SIMILARITY: Belongs to the cerato-platanin family. {ECO:0000305}.
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DR EMBL; AJ002026; CAA05149.1; -; mRNA.
DR EMBL; AAHF01000001; EAL93557.1; -; Genomic_DNA.
DR RefSeq; XP_755595.1; XM_750502.1.
DR AlphaFoldDB; O60022; -.
DR SMR; O60022; -.
DR STRING; 746128.CADAFUBP00002767; -.
DR Allergome; 3112; Asp f 15.0101.
DR Allergome; 67; Asp f 15.
DR EnsemblFungi; EAL93557; EAL93557; AFUA_2G12630.
DR GeneID; 3512975; -.
DR KEGG; afm:AFUA_2G12630; -.
DR VEuPathDB; FungiDB:Afu2g12630; -.
DR eggNOG; ENOG502SQTH; Eukaryota.
DR HOGENOM; CLU_111635_0_0_1; -.
DR InParanoid; O60022; -.
DR OMA; QCGTCYG; -.
DR OrthoDB; 1430841at2759; -.
DR BRENDA; 3.4.23.18; 508.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.40.10; -; 1.
DR InterPro; IPR010829; Cerato-platanin.
DR InterPro; IPR036908; RlpA-like_sf.
DR Pfam; PF07249; Cerato-platanin; 1.
DR SUPFAM; SSF50685; SSF50685; 1.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..152
FT /note="Allergen Asp f 15"
FT /id="PRO_0000004998"
FT DISULFID 53..90
FT /evidence="ECO:0000250"
FT DISULFID 93..148
FT /evidence="ECO:0000250"
FT CONFLICT 41
FT /note="Y -> RD (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 152 AA; 15944 MW; 5516BEBA23653CB5 CRC64;
MKFTTPISLI SLFVSSALAA PTPENEARDA IPVSVSYDPR YDNAGTSMND VSCSNGVNGL
VTKWPTFGSV PGFARIGGAP TIPGWNSPNC GKCYKLQYEQ NTIYVTAIDA APGGFNIATS
AMDQLTNGMA VELGRVQATY EEADPSHCAS GV
