FLJB_SALTY
ID FLJB_SALTY Reviewed; 506 AA.
AC P52616; P97159;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Phase 2 flagellin;
GN Name=fljB; Synonyms=H2; OrderedLocusNames=STM2771;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SL 375;
RX PubMed=7541401; DOI=10.1128/jb.177.13.3863-3864.1995;
RA Vanegas R.A., Joys T.M.;
RT "Molecular analyses of the phase-2 antigen complex 1,2, of Salmonella
RT spp.";
RL J. Bacteriol. 177:3863-3864(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38.
RX PubMed=6271461; DOI=10.1101/sqb.1981.045.01.005;
RA Silverman M., Zieg J., Mandel G., Simon M.;
RT "Analysis of the functional components of the phase variation system.";
RL Cold Spring Harb. Symp. Quant. Biol. 45:17-26(1981).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 483-506.
RC STRAIN=SJ2353;
RA Mingorance J., Tanaka S., Tominaga A., Enomoto M.;
RL Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC the filaments of bacterial flagella.
CC -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC -!- MISCELLANEOUS: Individual Salmonella serotypes usually alternate
CC between the production of 2 antigenic forms of flagella, termed phase 1
CC and phase 2, each specified by separate structural genes.
CC -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR EMBL; U17177; AAC43354.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21657.1; -; Genomic_DNA.
DR EMBL; V01370; CAA24655.1; -; Genomic_DNA.
DR EMBL; D26168; BAA05156.1; -; Genomic_DNA.
DR RefSeq; NP_461698.1; NC_003197.2.
DR RefSeq; WP_000079794.1; NC_003197.2.
DR PDB; 5YUD; EM; 4.28 A; C=31-52.
DR PDB; 6RGV; X-ray; 2.00 A; A=55-462.
DR PDBsum; 5YUD; -.
DR PDBsum; 6RGV; -.
DR AlphaFoldDB; P52616; -.
DR SMR; P52616; -.
DR STRING; 99287.STM2771; -.
DR PaxDb; P52616; -.
DR EnsemblBacteria; AAL21657; AAL21657; STM2771.
DR GeneID; 1254294; -.
DR KEGG; stm:STM2771; -.
DR PATRIC; fig|99287.12.peg.2923; -.
DR HOGENOM; CLU_011142_7_2_6; -.
DR OMA; IASQTTY; -.
DR PhylomeDB; P52616; -.
DR BioCyc; SENT99287:STM2771-MON; -.
DR Reactome; R-GGA-433822; NFkB and MAPK activation mediated by TRAF6.
DR Reactome; R-GGA-451534; TLR5 cascade.
DR Reactome; R-GGA-977240; MyD88 cascade initiated on plasma membrane.
DR Reactome; R-HSA-844623; The IPAF inflammasome.
DR PHI-base; PHI:7448; -.
DR PHI-base; PHI:8373; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 6.10.10.10; -; 1.
DR InterPro; IPR001492; Flagellin.
DR InterPro; IPR046358; Flagellin_C.
DR InterPro; IPR042187; Flagellin_C_sub2.
DR InterPro; IPR014981; Flagellin_D3.
DR InterPro; IPR001029; Flagellin_N.
DR PANTHER; PTHR42792; PTHR42792; 1.
DR Pfam; PF00700; Flagellin_C; 1.
DR Pfam; PF08884; Flagellin_D3; 1.
DR Pfam; PF00669; Flagellin_N; 1.
DR PRINTS; PR00207; FLAGELLIN.
PE 1: Evidence at protein level;
KW 3D-structure; Bacterial flagellum; Reference proteome; Secreted.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..506
FT /note="Phase 2 flagellin"
FT /id="PRO_0000182580"
FT CONFLICT 38
FT /note="I -> S (in Ref. 3; CAA24655)"
FT /evidence="ECO:0000305"
FT HELIX 55..99
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 106..129
FT /evidence="ECO:0007829|PDB:6RGV"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 142..147
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 149..151
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 155..160
FT /evidence="ECO:0007829|PDB:6RGV"
FT TURN 165..169
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 180..185
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 187..192
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 205..212
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 216..221
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 222..224
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 227..229
FT /evidence="ECO:0007829|PDB:6RGV"
FT TURN 230..233
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 234..242
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 244..249
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 251..257
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 259..261
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 286..291
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 296..304
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 309..313
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 316..323
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 329..338
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 341..347
FT /evidence="ECO:0007829|PDB:6RGV"
FT TURN 349..351
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 354..356
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 358..362
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 368..372
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 374..376
FT /evidence="ECO:0007829|PDB:6RGV"
FT TURN 377..379
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 382..387
FT /evidence="ECO:0007829|PDB:6RGV"
FT STRAND 390..393
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 394..397
FT /evidence="ECO:0007829|PDB:6RGV"
FT TURN 402..404
FT /evidence="ECO:0007829|PDB:6RGV"
FT HELIX 419..458
FT /evidence="ECO:0007829|PDB:6RGV"
SQ SEQUENCE 506 AA; 52536 MW; 3A4051A9AF7AF88B CRC64;
MAQVINTNSL SLLTQNNLNK SQSALGTAIE RLSSGLRINS AKDDAAGQAI ANRFTANIKG
LTQASRNAND GISIAQTTEG ALNEINNNLQ RVRELAVQSA NSTNSQSDLD SIQAEITQRL
NEIDRVSGQT QFNGVKVLAQ DNTLTIQVGA NDGETIDIDL KQINSQTLGL DSLNVQKAYD
VKDTAVTTKA YANNGTTLDV SGLDDAAIKA ATGGTNGTAS VTGGAVKFDA DNNKYFVTIG
GFTGADAAKN GDYEVNVATD GTVTLAAGAT KTTMPAGATT KTEVQELKDT PAVVSADAKN
ALIAGGVDAT DANGAELVKM SYTDKNGKTI EGGYALKAGD KYYAADYDEA TGAIKAKTTS
YTAADGTTKT AANQLGGVDG KTEVVTIDGK TYNASKAAGH DFKAQPELAE AAAKTTENPL
QKIDAALAQV DALRSDLGAV QNRFNSAITN LGNTVNNLSE ARSRIEDSDY ATEVSNMSRA
QILQQAGTSV LAQANQVPQN VLSLLR
