ID   FLMA_ECO57              Reviewed;          52 AA.
AC   P62671; P16077;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Stable plasmid inheritance protein;
DE   AltName: Full=F leading maintenance protein;
GN   Name=flmA; Synonyms=parB, stm; OrderedLocusNames=L7090, ECO57PM53;
OS   Escherichia coli O157:H7.
OG   Plasmid pO157.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=9722640; DOI=10.1093/nar/26.18.4196;
RA   Burland V., Shao Y., Perna N.T., Plunkett G. III, Sofia H.J.,
RA   Blattner F.R.;
RT   "The complete DNA sequence and analysis of the large virulence plasmid of
RT   Escherichia coli O157:H7.";
RL   Nucleic Acids Res. 26:4196-4204(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=9628576; DOI=10.1093/dnares/5.1.1;
RA   Makino K., Ishii K., Yasunaga T., Hattori M., Yokoyama K., Yatsudo H.C.,
RA   Kubota Y., Yamaichi Y., Iida T., Yamamoto K., Honda T., Han C.G.,
RA   Ohtsubo A., Kasamatsu M., Hayashi T., Kuhara S., Shinagawa H.;
RT   "Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an
RT   enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak.";
RL   DNA Res. 5:1-9(1998).
CC   -!- FUNCTION: Toxic component of a type I toxin-antitoxin (TA) system (By
CC       similarity). Part of the plasmid maintenance system, encodes a toxic
CC       protein that collapses the transmembrane potential and arrests
CC       respiration (By similarity). When the adjacent non-translated flmB
CC       (sok) gene is disrupted FlmA no longer functions in plasmid maintenance
CC       (i.e. FlmB probably encodes an antisense antitoxin RNA) (By
CC       similarity). Translation of FlmA may be coupled to the upstream flmC
CC       gene (By similarity). {ECO:0000250|UniProtKB:P62670}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0ACG4}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Hok/Gef family. {ECO:0000305}.
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DR   EMBL; AF074613; AAC70158.1; -; Genomic_DNA.
DR   EMBL; AB011549; BAA31810.1; -; Genomic_DNA.
DR   PIR; JS0432; BVECMA.
DR   RefSeq; NP_052660.1; NC_002128.1.
DR   RefSeq; WP_001302184.1; NZ_SWKA01000002.1.
DR   AlphaFoldDB; P62671; -.
DR   SMR; P62671; -.
DR   EnsemblBacteria; AAC70158; AAC70158; Z_L7090.
DR   EnsemblBacteria; BAA31810; BAA31810; BAA31810.
DR   GeneID; 1789673; -.
DR   KEGG; ece:Z_L7090; -.
DR   KEGG; ecs:pO157p53; -.
DR   PATRIC; fig|83334.175.peg.3555; -.
DR   HOGENOM; CLU_177638_2_1_6; -.
DR   OMA; NIRIASY; -.
DR   Proteomes; UP000000558; Plasmid pO157.
DR   Proteomes; UP000002519; Plasmid pO157.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000021; Hok/gef_toxin.
DR   InterPro; IPR018084; Hok/gef_toxin_CS.
DR   Pfam; PF01848; HOK_GEF; 1.
DR   PRINTS; PR00281; HOKGEFTOXIC.
DR   PROSITE; PS00556; HOK_GEF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Plasmid; Reference proteome;
KW   Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT   CHAIN           1..52
FT                   /note="Stable plasmid inheritance protein"
FT                   /id="PRO_0000199046"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   52 AA;  6108 MW;  DFF2E2175DA23586 CRC64;
     MKLPRSSLVW CVLIVCLTLL IFTYLTRKSL CEIRYRDGYR EVAAFMAYES GK