ID   FLMC1_ECOLI             Reviewed;          70 AA.
AC   P11519;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Protein FlmC;
DE   AltName: Full=F-plasmid maintenance protein C;
GN   Name=flmC; Synonyms=ORF70 {ECO:0000303|PubMed:3049248};
GN   OrderedLocusNames=ECOK12F065;
OS   Escherichia coli (strain K12).
OG   Plasmid F.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / AB1157; PLASMID=F;
RX   PubMed=3049248; DOI=10.1016/0378-1119(88)90362-9;
RA   Loh S.M., Cram D.S., Skurray R.A.;
RT   "Nucleotide sequence and transcriptional analysis of a third function (Flm)
RT   involved in F-plasmid maintenance.";
RL   Gene 66:259-268(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / CR63;
RA   Shimizu H., Saitoh Y., Suda Y., Uehara K., Sampei G., Mizobuchi K.;
RT   "Complete nucleotide sequence of the F plasmid: its implications for
RT   organization and diversification of plasmid genomes.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a type I toxin-antitoxin (TA) system (Probable).
CC       Either this protein or sequences upstream of it are required for
CC       translation of downstream flmA; this could be translationally coupled
CC       to flmA (PubMed:3049248). {ECO:0000269|PubMed:3049248}.
CC   -!- INDUCTION: Part of the flmC-flmA operon; the antisense antitoxin RNA
CC       flmB of this system overlaps the ribosome-binding site and first 3
CC       codons of this gene on the opposite strand.
CC       {ECO:0000269|PubMed:3049248}.
CC   -!- DISRUPTION PHENOTYPE: A plasmid unable to express the start codon of
CC       this protein can be lost without detriment to the bacteria, when
CC       normally the plasmid is not lost due to the Flm plasmid maintenance
CC       system. {ECO:0000269|PubMed:3049248}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF106329; AAA99215.1; -; Genomic_DNA.
DR   EMBL; AP001918; BAA97935.1; -; Genomic_DNA.
DR   PIR; JS0433; JS0433.
DR   RefSeq; NP_061444.1; NC_002483.1.
DR   RefSeq; WP_001306679.1; NC_002483.1.
DR   AlphaFoldDB; P11519; -.
DR   PRIDE; P11519; -.
DR   PRO; PR:P11519; -.
DR   InterPro; IPR035273; DUF5431.
DR   Pfam; PF17496; DUF5431; 1.
PE   2: Evidence at transcript level;
KW   Plasmid; Toxin-antitoxin system.
FT   CHAIN           1..70
FT                   /note="Protein FlmC"
FT                   /id="PRO_0000068355"
SQ   SEQUENCE   70 AA;  7894 MW;  DABF895A00DCF3B6 CRC64;
     MLRQHQDSLL LRFAQGEEGH ETTTQLSCLV CVDRVSHTVD IHLSDTKIAV RDSLQRRIQG
     GGGFHGLRIR