ID   FLO8_YEAS2              Reviewed;         802 AA.
AC   C7GS77;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Transcriptional activator FLO8;
DE   AltName: Full=Protein PDH5;
GN   Name=FLO8; Synonyms=PDH5; ORFNames=C1Q_03223;
OS   Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=574961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAY291;
RX   PubMed=19812109; DOI=10.1101/gr.091777.109;
RA   Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V.C.,
RA   Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O., Noronha M.F.,
RA   Dominska M., Andrietta M.G.S., Andrietta S.R., Cunha A.F., Gomes L.H.,
RA   Tavares F.C.A., Alcarde A.R., Dietrich F.S., McCusker J.H., Petes T.D.,
RA   Pereira G.A.G.;
RT   "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT   bioethanol production.";
RL   Genome Res. 19:2258-2270(2009).
CC   -!- FUNCTION: Required for diploid filamentous growth, haploid invasive
CC       growth and flocculation. Putative transcriptional activator of FLO1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FLO8 family. {ECO:0000305}.
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DR   EMBL; ACFL01000174; EEU06340.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7GS77; -.
DR   SMR; C7GS77; -.
DR   Proteomes; UP000008073; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031326; P:regulation of cellular biosynthetic process; IEA:UniProt.
DR   InterPro; IPR006594; LisH.
DR   SMART; SM00667; LisH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..802
FT                   /note="Transcriptional activator FLO8"
FT                   /id="PRO_0000392095"
FT   DOMAIN          76..108
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          28..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          434..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          647..757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..409
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..613
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   802 AA;  87193 MW;  B4AB2BFDCDFE8147 CRC64;
     MSYKVNSSYP DSIPPTEQPY MASQYKQDLQ SNIAMATNSE QQRQQQQQQQ QQQQQQQQWI
     NQPTAENSDL KEKMNCKNTL NEYIFDFLTK SSLKNTAAAF AQDAHLDRDK GQNPIDGPKS
     KENNGNQNTF SKVVDTPQGF LYEWWQIFWD IFNTSSSRGG SEFAQQYYQL VLQEQRQEQI
     YRSLAVHAAR LQHDAERRGE YSNEDIDPMH LAAMMLGNPM APAVQMRNVN MNPIPIPMVG
     NPIVNNFSIP PYNNANPTTG ATAVAPTAPP SGDFTNVGPT QNRSQNVTGW PVYNYPMQPT
     TENPVGNPCN NNTTNNTTNN KSPVNQPKSL KTMHSTDKPN NVPTSKSTRS RSATSKAKGK
     VKAGLVAKRR RKNNTATVSA GSTNAGSPNI TTPGSTTSEP AMVGSRVNKT PRSDIATNFR
     NQAIIFGEED IYSNSKSSPS LDGASPSALV SKQPTKVRKN TKKASTSAFP VESANKLGGN
     SVVTGKKRSP PNTRVSRRKS TPSVILNADA TKDENNMLRT FSNTTAPNIH SAPPTKTANS
     LPFPGINLGS FNKPAVSSPL SSVTESCFDP ESGKIAGKNG PKRAVNSKVS ASSPLSIATP
     PSGDAQKQRS SKVPGNVVIK PPHGFSTTNL NITLKSSKII TSQNNTVSQE LPNGGNILEA
     QVGNDSRSSK GNRNTLSTSE EKKPSSNNQG YDFDALKNPS SLLFPNQAYA SNNRTPNENS
     NVTDETSAST NNGDNDNTLI QPSSNVGTTL GPQQTSTYEN QNVHSQNLKF GNIGMVEDQG
     PDYDLNLLDT NENDFNFINW EG