ID   FLO8_YEAS8              Reviewed;         799 AA.
AC   C8Z7C7;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Transcriptional activator FLO8;
DE   AltName: Full=Protein PDH5;
GN   Name=FLO8; Synonyms=PDH5; ORFNames=EC1118_1E8_2432g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: Required for diploid filamentous growth, haploid invasive
CC       growth and flocculation. Putative transcriptional activator of FLO1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FLO8 family. {ECO:0000305}.
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DR   EMBL; FN393067; CAY79293.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8Z7C7; -.
DR   EnsemblFungi; CAY79293; CAY79293; EC1118_1E8_2421g.
DR   HOGENOM; CLU_351656_0_0_1; -.
DR   Proteomes; UP000000286; Chromosome V, Scaffold EC1118_1E8.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031326; P:regulation of cellular biosynthetic process; IEA:UniProt.
DR   InterPro; IPR006594; LisH.
DR   SMART; SM00667; LisH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..799
FT                   /note="Transcriptional activator FLO8"
FT                   /id="PRO_0000392098"
FT   DOMAIN          73..105
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          37..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          705..758
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..351
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        582..610
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   799 AA;  86805 MW;  C06BACF4356B7EF8 CRC64;
     MSYKVNSSYP DSIPPTEQPY MASQYKQDLQ SNIAMATNSE QQRQQQQQQQ QQQQQWINQP
     TAENSDLKEK MNCKNTLNEY IFDFLTKSSL KNTAAAFAQD AHLDRDKGQN PIDGPKSKEN
     NGNQNTFSKV VDTPQGFLYE WWQIFWDIFN TSSSRGGSEF AQQYYQLVLQ EQRQEQIYRS
     LAVHAARLQH DAERRGEYSN EDIDPMHLAA MMLGNPMAPA VQMRNVNMNP IPIPMVGNPI
     VNNFSIPPYN NANPTTGATA VAPTAPPSGD FTNVGPTQNR SQNVTGWPVY NYPMQPTTEN
     PVGNPCNNNT TNNTTNNKSP VNQPKSLKTM HSTDKPNNVP TSKSTRSRSA TSKAKGKVKA
     GLVAKRRRKN NTATVSAGST NAGSPNITTP GSATSEPAMV GSRVNKTPRS DIATNFRNQA
     IIFGEEDIYS NSKSSPSLDG ASPSALASKQ PTKVRKNTKK ASTSAFPVES TNKLGGNSVV
     TGKKRSPPNT RMSRRKSTPS VILNADATKD ENNMLRTFSN TIAPNIHSAP PTKTANSLPF
     PGINLGSFNK PAVSSPLSSV TESCFDPESG KIAGKNGPKR AVNSKVSASS PLSIATPRSG
     DAQKQRSSKV PGNVVIKPPH GFSTTNLNIT LKNSKIITSQ NNTVSQELPN GGNILEAQVG
     NDSRSSKGNR NTLSTPEEKK PSSNNQGYDF DALKNSSSLL FPNQAYASNN RTPNENSNVA
     DETSASTNSG DNDNTLIQPS SNVGTTLGPQ QTSTNENQNV HSQNLKFGNI GMVEDQGPDY
     DLNLLDTNEN DFNFINWEG