FLOA_ALKCK
ID FLOA_ALKCK Reviewed; 340 AA.
AC Q5WHE8;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=ABC1672;
OS Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=66692;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSM-K16;
RA Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA Kawai S., Ito S., Horikoshi K.;
RT "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT K16.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC increase in number as cells age. Flotillins are thought to be important
CC factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC Membrane raft {ECO:0000255|HAMAP-Rule:MF_01562}; Single-pass membrane
CC protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR EMBL; AP006627; BAD64207.1; -; Genomic_DNA.
DR RefSeq; WP_011246516.1; NC_006582.1.
DR AlphaFoldDB; Q5WHE8; -.
DR SMR; Q5WHE8; -.
DR STRING; 66692.ABC1672; -.
DR EnsemblBacteria; BAD64207; BAD64207; ABC1672.
DR KEGG; bcl:ABC1672; -.
DR eggNOG; COG4864; Bacteria.
DR HOGENOM; CLU_836378_0_0_9; -.
DR OMA; GIMDYYR; -.
DR OrthoDB; 827327at2; -.
DR Proteomes; UP000001168; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01562; FloA; 1.
DR InterPro; IPR022853; FloA.
DR Pfam; PF12127; YdfA_immunity; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..340
FT /note="Flotillin-like protein FloA"
FT /id="PRO_0000232545"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT REGION 314..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 36663 MW; 3922FAB976F6E37B CRC64;
MNDSTIFVLI AIALAIILIA ILFTFVPVAL WISAIAAGVK IGIFELVGMR LRRVVPARVV
NPLIKAVKAG LDLDTSRLEG HYLAGGNVDR VVNALIAAQR ANIDLSFERA AAIDLAGRDV
LEAVQMSVNP KVIETPFIAG VAMDGIEVKA KARITVRANI DRLVGGAGED TVIARVGEGI
VSTIGSQNDH KKVLENPDMI SQTVLSKGLD SGTAFEILSI DIADIDIGKN IGAELQTDQA
QADKNIAQAK AEERRAMAVA KEQEMKARVE EMRAKVVEAE AEVPMALSEA LRQGHMGVMD
YMNYQNVMAD TDMRDSISKA SGTKEEQHSK NDPRNRNVDK