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FLOA_ALKCK
ID   FLOA_ALKCK              Reviewed;         340 AA.
AC   Q5WHE8;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=ABC1672;
OS   Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16;
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC       Membrane raft {ECO:0000255|HAMAP-Rule:MF_01562}; Single-pass membrane
CC       protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; AP006627; BAD64207.1; -; Genomic_DNA.
DR   RefSeq; WP_011246516.1; NC_006582.1.
DR   AlphaFoldDB; Q5WHE8; -.
DR   SMR; Q5WHE8; -.
DR   STRING; 66692.ABC1672; -.
DR   EnsemblBacteria; BAD64207; BAD64207; ABC1672.
DR   KEGG; bcl:ABC1672; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_9; -.
DR   OMA; GIMDYYR; -.
DR   OrthoDB; 827327at2; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..340
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_0000232545"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT   REGION          314..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..340
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  36663 MW;  3922FAB976F6E37B CRC64;
     MNDSTIFVLI AIALAIILIA ILFTFVPVAL WISAIAAGVK IGIFELVGMR LRRVVPARVV
     NPLIKAVKAG LDLDTSRLEG HYLAGGNVDR VVNALIAAQR ANIDLSFERA AAIDLAGRDV
     LEAVQMSVNP KVIETPFIAG VAMDGIEVKA KARITVRANI DRLVGGAGED TVIARVGEGI
     VSTIGSQNDH KKVLENPDMI SQTVLSKGLD SGTAFEILSI DIADIDIGKN IGAELQTDQA
     QADKNIAQAK AEERRAMAVA KEQEMKARVE EMRAKVVEAE AEVPMALSEA LRQGHMGVMD
     YMNYQNVMAD TDMRDSISKA SGTKEEQHSK NDPRNRNVDK
 
 
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