FLOA_ALKOO
ID FLOA_ALKOO Reviewed; 333 AA.
AC A8MG60;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=Clos_1242;
OS Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain
OS OhILAs)).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Alkaliphilus.
OX NCBI_TaxID=350688;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OhILAs;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E.,
RA Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.;
RT "Complete genome of Alkaliphilus oremlandii OhILAs.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC increase in number as cells age. Flotillins are thought to be important
CC factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR EMBL; CP000853; ABW18788.1; -; Genomic_DNA.
DR RefSeq; WP_012159100.1; NC_009922.1.
DR AlphaFoldDB; A8MG60; -.
DR SMR; A8MG60; -.
DR STRING; 350688.Clos_1242; -.
DR PRIDE; A8MG60; -.
DR EnsemblBacteria; ABW18788; ABW18788; Clos_1242.
DR KEGG; aoe:Clos_1242; -.
DR eggNOG; COG4864; Bacteria.
DR HOGENOM; CLU_836378_0_0_9; -.
DR OMA; GIMDYYR; -.
DR OrthoDB; 827327at2; -.
DR Proteomes; UP000000269; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01562; FloA; 1.
DR InterPro; IPR022853; FloA.
DR Pfam; PF12127; YdfA_immunity; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Flotillin-like protein FloA"
FT /id="PRO_0000318627"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ SEQUENCE 333 AA; 35540 MW; 1489D8983C4C1F8C CRC64;
MPEVVFLLIV VAIAFIVLSI ILSFIPVGLW ITALFSGVKV GIFTLVGMRF RRVQPNRIVG
PLIKATKAGL NLDIDDLEAH YLAGGDVNSV VDALIAAQRA EIGLEFERAA AIDLAGRNVL
EAVQVSVNPK VIETPKISAV AKDGIEVMVK AKVTVRANIE RLVGGAGEET IIARVGEGIV
TTVGSALSHK DVLENPDSIS KMVLGKGLDA GTAFEILSID IADIDIARNI GAQLQTDQAE
ADKRIAQAKA EEKRAMAVAR EQEMKAAVIE MKAKVVEAEA EVPRAIAAAL REGKLGVMDY
YNLQNVAADT TMRESIAKIS KDDNDSHGKD ITK