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FLOA_BACFN
ID   FLOA_BACFN              Reviewed;         333 AA.
AC   Q5LG75;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=BF1143;
OS   Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS   / NCTC 9343 / Onslow).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=272559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow;
RX   PubMed=15746427; DOI=10.1126/science.1107008;
RA   Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA   Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA   Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA   Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA   Barrell B.G., Parkhill J.;
RT   "Extensive DNA inversions in the B. fragilis genome control variable gene
RT   expression.";
RL   Science 307:1463-1465(2005).
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC       Membrane raft {ECO:0000255|HAMAP-Rule:MF_01562}; Single-pass membrane
CC       protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; CR626927; CAH06866.1; -; Genomic_DNA.
DR   RefSeq; WP_005785715.1; NC_003228.3.
DR   AlphaFoldDB; Q5LG75; -.
DR   SMR; Q5LG75; -.
DR   STRING; 272559.BF9343_1085; -.
DR   PRIDE; Q5LG75; -.
DR   EnsemblBacteria; CAH06866; CAH06866; BF9343_1085.
DR   GeneID; 66329885; -.
DR   KEGG; bfs:BF9343_1085; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_10; -.
DR   OMA; GIMDYYR; -.
DR   OrthoDB; 827327at2; -.
DR   Proteomes; UP000006731; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_0000232550"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   333 AA;  35887 MW;  C2AE23BDBB1DB7FA CRC64;
     MNVEPMYLTI FLIAGGIIFL VLFFHYVPFF LWLSAKVSGV NISLVQLFLM RIRNVPPYII
     VPGMIEAHKA GLSNITRDEL EAHYLAGGHV ERVVHALVSA SKANIELPFQ MATAIDLAGR
     DVFEAVQMSV NPKVIDTPPV TAVAKDGIQL IAKARVTVRA NIRQLVGGAG EDTILARVGE
     GIVSSIGSSE NHKSVLENPD SISKLVLRKG LDAGTAFEIL SIDIADIDIG KNIGAALQID
     QANADKNIAQ AKAEERRAMA VATEQEMKAK AEEARANVIQ AEAEVPKAMA EAFRSGNLGI
     MDYYKMKNIQ ADTSMRENIA KPIGGATSKP LSD
 
 
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