ID   FLOA_BACLD              Reviewed;         330 AA.
AC   Q65H64; Q62SM1;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   OrderedLocusNames=BLi02729, BL01411;
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=279010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15383718; DOI=10.1159/000079829;
RA   Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA   Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT   "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT   with great industrial potential.";
RL   J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC       raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; AE017333; AAU41600.1; -; Genomic_DNA.
DR   EMBL; CP000002; AAU24238.1; -; Genomic_DNA.
DR   RefSeq; WP_003183647.1; NC_006322.1.
DR   AlphaFoldDB; Q65H64; -.
DR   SMR; Q65H64; -.
DR   STRING; 279010.BL01411; -.
DR   EnsemblBacteria; AAU24238; AAU24238; BL01411.
DR   GeneID; 66215284; -.
DR   KEGG; bld:BLi02729; -.
DR   KEGG; bli:BL01411; -.
DR   PATRIC; fig|279010.13.peg.2773; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_9; -.
DR   OMA; GIMDYYR; -.
DR   OrthoDB; 827327at2; -.
DR   BioCyc; BLIC279010:BLI_RS13510-MON; -.
DR   Proteomes; UP000000606; Chromosome.
DR   Bgee; BL01411; Expressed in ovary and 12 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_0000232547"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   330 AA;  35656 MW;  4652A193569DB8DB CRC64;
     MDPSTLFLLL IIAAGIILLA VFFTFVPVML WISALAAGVK ISIFTLIGMR LRRVIPNRVV
     NPLIKAHKAG LDVAINQLES HYLAGGNVDR VVNALIAAQR ANIELTFARC AAIDLAGRDV
     LEAVQMSVNP KVIETPFIAG VAMDGIEVKA KARITVRANI DRLVGGAGEE TIIARVGEGI
     VSTIGSSDNH KKVLENPDMI SQTVLSKGLD SGTAFEILSI DIADVDIGKN IGAILQTDQA
     EADKNIAQAK AEERRAMAVA QEQEMRARVE EMRAKVVEAE AEVPLAMSEA LRSGKIGVMD
     YLNMKNIDAD TDMRDSFGKM TKDQNEEDHK