ID   FLOA_BACTN              Reviewed;         333 AA.
AC   Q89Z22;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=BT_4555;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC       Membrane raft {ECO:0000255|HAMAP-Rule:MF_01562}; Single-pass membrane
CC       protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; AE015928; AAO79660.1; -; Genomic_DNA.
DR   RefSeq; NP_813466.1; NC_004663.1.
DR   RefSeq; WP_008760314.1; NZ_UYXG01000024.1.
DR   AlphaFoldDB; Q89Z22; -.
DR   SMR; Q89Z22; -.
DR   STRING; 226186.BT_4555; -.
DR   PaxDb; Q89Z22; -.
DR   PRIDE; Q89Z22; -.
DR   DNASU; 1072218; -.
DR   EnsemblBacteria; AAO79660; AAO79660; BT_4555.
DR   GeneID; 60925729; -.
DR   KEGG; bth:BT_4555; -.
DR   PATRIC; fig|226186.12.peg.4636; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_10; -.
DR   InParanoid; Q89Z22; -.
DR   OMA; GIMDYYR; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_0000232551"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   333 AA;  35887 MW;  215C810DD40E5618 CRC64;
     METSLYLPIV LIVGGIIFLI LFFHYVPFFL WLSAKVSGVN ISLIQLFLMR IRNVPPYIIV
     PGMIEAHKAG LKNITRDELE AHYLAGGHVE KVVHALVSAS KANIELSFQM ATAIDLAGRD
     VFEAVQMSVN PKVIDTPPVT AVAKDGIQLI AKARVTVRAS IKQLVGGAGE DTILARVGEG
     IVSSIGSSEN HKSVLENPDS ISKLVLRKGL DAGTAFEILS IDIADIDIGK NIGAALQIDQ
     ANADKNIAQA KAEERRAMAV ASEQEMKAKA QEARAKVIEA EAEVPKAMAE AFRSGNLGIM
     DYYRMKNIEA DTSMRENIAK PTTGGTTNQP LSK