ID   FLOA_DICT6              Reviewed;         329 AA.
AC   B5YD74;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=DICTH_0602;
OS   Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12).
OC   Bacteria; Dictyoglomi; Dictyoglomales; Dictyoglomaceae; Dictyoglomus.
OX   NCBI_TaxID=309799;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35947 / DSM 3960 / H-6-12;
RX   PubMed=24558247; DOI=10.1128/genomea.00109-14;
RA   Coil D.A., Badger J.H., Forberger H.C., Riggs F., Madupu R., Fedorova N.,
RA   Ward N., Robb F.T., Eisen J.A.;
RT   "Complete Genome Sequence of the Extreme Thermophile Dictyoglomus
RT   thermophilum H-6-12.";
RL   Genome Announc. 2:0-0(2014).
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC       Membrane raft {ECO:0000255|HAMAP-Rule:MF_01562}; Single-pass membrane
CC       protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; CP001146; ACI19589.1; -; Genomic_DNA.
DR   RefSeq; WP_012548221.1; NC_011297.1.
DR   AlphaFoldDB; B5YD74; -.
DR   SMR; B5YD74; -.
DR   STRING; 309799.DICTH_0602; -.
DR   EnsemblBacteria; ACI19589; ACI19589; DICTH_0602.
DR   KEGG; dth:DICTH_0602; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_0; -.
DR   OMA; GIMDYYR; -.
DR   OrthoDB; 827327at2; -.
DR   Proteomes; UP000001733; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..329
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_1000199712"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   329 AA;  35173 MW;  0EC6F9076D7981A3 CRC64;
     MSLLWGFLIL ILVLIFLGIF FSFVPLGLWI SALAAGVSIK ITDLIGMRLR RVPPGVIINS
     LIKAHKAGLS EVTLDKLEAH YLAGGNVDKV VNALIAAQRA GIPLTFEKAA AIDLAGRDVL
     EAVQMSVNPK VIETPVVAAV AKDGIELKAK ARVTVRANIE RLVGGAGEAT IIARVGEGIV
     TTIGSAESYK EVLENPDSIS KTVLAKGLDA GTAFEIVSID IADVDVGNNV GARLKMDQAE
     ADMRIAQAQA ESRRALAIAR EQEMKALTQE MRARLIEAEK EVPLAVAEAL RSGKIGVLDY
     YTLKNIMADT AMREAISKLG QKEEEGRKD