ID   FLOA_EXIS2              Reviewed;         327 AA.
AC   B1YL66;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=Exig_0818;
OS   Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS   255-15).
OC   Bacteria; Firmicutes; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=262543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA   Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA   Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC       raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; CP001022; ACB60298.1; -; Genomic_DNA.
DR   RefSeq; WP_012369722.1; NC_010556.1.
DR   AlphaFoldDB; B1YL66; -.
DR   SMR; B1YL66; -.
DR   STRING; 262543.Exig_0818; -.
DR   PRIDE; B1YL66; -.
DR   EnsemblBacteria; ACB60298; ACB60298; Exig_0818.
DR   KEGG; esi:Exig_0818; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_9; -.
DR   OMA; GIMDYYR; -.
DR   OrthoDB; 827327at2; -.
DR   Proteomes; UP000001681; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_1000199714"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   327 AA;  34954 MW;  626961592AA3583D CRC64;
     MTPELLTVLL ITGGILIFLA IFFTLVPIPL WISSLAAGVR VSIFTLVGMR LRRVTPSKIV
     NPLIKAVKAG INLNTNQLES HYLAGGNVDR VVNALIAAHR ANIELSFERA AAIDLAGRNV
     LEAVQMSVNP KVIETPFIAG VAMNGIEVKA KARITVRANI DRLVGGAGEE TVIARVGEGV
     ISTIGSCQDQ KEVLENPEMI SRTVLAKGLD SGTAFEILSI DIADVDIGKN IGAVLQTDQA
     EADKNIAQAK AEERRAMAIA SEQEMKSRVE EMRAKVVAAE AEVPLAIAEA LRDGNFSVMD
     YANYLNVTAD TKMRQAIGGQ SSPNDTQ