ID   FLOA_OCEIH              Reviewed;         330 AA.
AC   Q8EPX2;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=OB1959;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC       raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; BA000028; BAC13915.1; -; Genomic_DNA.
DR   RefSeq; WP_011066356.1; NC_004193.1.
DR   AlphaFoldDB; Q8EPX2; -.
DR   SMR; Q8EPX2; -.
DR   STRING; 221109.22777643; -.
DR   EnsemblBacteria; BAC13915; BAC13915; BAC13915.
DR   KEGG; oih:OB1959; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_9; -.
DR   OMA; GIMDYYR; -.
DR   OrthoDB; 827327at2; -.
DR   PhylomeDB; Q8EPX2; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_0000232555"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   330 AA;  35453 MW;  F103834126288CB2 CRC64;
     MENSIILPII IIAAVLIALA ILFTFVPVAL WISALAAGVK ISIFTLIGMR LRRVVPNRVI
     NPLIKAHKAG LNVKTNQLES HYLAGGNVDR VVNALIAAHR ANIDLPFERG AAIDLAGRDV
     LEAVQMSVNP KVIETPFIAG IAMDGIEVKA LARITVRANI DRLVGGAGEE TIIARVGEGV
     VSTIGSSDHH KQVLENPDSI SQTVLSKGLD SGTAFEILSI DIADVDIGKN IGAILQTDQA
     EADKNIAQAK AEERRAMAVA QEQEMVARVQ EMRAKVVEAE ADVPLALAEA LRSGKMGVMD
     YMNYQNIDAD TDMRDSIGKL SKENKDDDQQ