ID   FLOA_PARD8              Reviewed;         330 AA.
AC   A6LDT3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=BDI_2116;
OS   Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS   5825 / NCTC 11152).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=435591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC       raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000140; ABR43847.1; -; Genomic_DNA.
DR   RefSeq; WP_008780036.1; NC_009615.1.
DR   AlphaFoldDB; A6LDT3; -.
DR   SMR; A6LDT3; -.
DR   STRING; 435591.BDI_2116; -.
DR   DNASU; 5307265; -.
DR   EnsemblBacteria; ABR43847; ABR43847; BDI_2116.
DR   KEGG; pdi:BDI_2116; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_10; -.
DR   OMA; GIMDYYR; -.
DR   OrthoDB; 827327at2; -.
DR   BioCyc; PDIS435591:G1G5A-2170-MON; -.
DR   Proteomes; UP000000566; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_0000318629"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   330 AA;  35644 MW;  3E6A726B7C6CC775 CRC64;
     MEITFLPLIL LGAAVLLLAI FFYYVPFLLW ISAKVSGVNI SLIQLFLMRI RKVPPYIITR
     AMIEAHKAGI KTLTRDELEA HYLAGGHVEK VVHALVSASK ANIDLPFQMA TAIDLAGRDV
     FEAVQMSVNP KVIDTPPVTA VAKDGIQLIA KARVTVRANI KQLVGGAGEE TILARVGEGI
     VSSIGSSESH KTVLENPDSI SKLVLRKGLD AGTAFEILSI DIADIDIGKN IGAFLQMDQA
     QADKNIAQAK AEERRAMAVA LEQEMKAKAQ EARAKVIEAE AEVPKAMADA FRTGNLGVMD
     YYKMKNIEAD TSMREAIAKP TGAPSKPLKD