FLOA_PHOV8
ID FLOA_PHOV8 Reviewed; 332 AA.
AC A6L6E5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=BVU_3648;
OS Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Phocaeicola.
OX NCBI_TaxID=435590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC 11154;
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC increase in number as cells age. Flotillins are thought to be important
CC factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC Membrane raft {ECO:0000255|HAMAP-Rule:MF_01562}; Single-pass membrane
CC protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR EMBL; CP000139; ABR41259.1; -; Genomic_DNA.
DR RefSeq; WP_005839405.1; NC_009614.1.
DR AlphaFoldDB; A6L6E5; -.
DR SMR; A6L6E5; -.
DR STRING; 435590.BVU_3648; -.
DR DNASU; 5304607; -.
DR EnsemblBacteria; ABR41259; ABR41259; BVU_3648.
DR GeneID; 56617923; -.
DR GeneID; 66749473; -.
DR KEGG; bvu:BVU_3648; -.
DR eggNOG; COG4864; Bacteria.
DR HOGENOM; CLU_836378_0_0_10; -.
DR OMA; GIMDYYR; -.
DR Proteomes; UP000002861; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01562; FloA; 1.
DR InterPro; IPR022853; FloA.
DR Pfam; PF12127; YdfA_immunity; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..332
FT /note="Flotillin-like protein FloA"
FT /id="PRO_1000069041"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ SEQUENCE 332 AA; 35991 MW; 54526974371400E4 CRC64;
MIEPNYLPFI LIGGGIIFVV LFFHYVPFFL WLSAKVSGVR ISLVQLFLMR IRNVPPYVIV
PAMIEAHKAG LSNITRDELE AHYMAGGHVE KVVHALVSAS KANIELSFQM ATGIDLAGRD
VFEAVQMSVN PKVIDTPPVT AVAKDGIQLI AKARVTVRAN IRQLVGGAGE DTILARVGEG
IVSSIGSSEN HKSVLENPDS ISKLVLRKGL DAGTAFEILS IDIADIDIGR NIGAALQIDQ
ANADKNIAQA KAEERRAMAV ALEQEMKAKA EEARANVIQA EAEVPKAMAE AFRSGNLGIM
DYYRMKNIQA DTSMRENIAK PETTFGNEPL SK