FLOA_STAAR
ID FLOA_STAAR Reviewed; 329 AA.
AC Q6GGC7;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=SAR1650;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC increase in number as cells age. Flotillins are thought to be important
CC factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX571856; CAG40645.1; -; Genomic_DNA.
DR RefSeq; WP_000492114.1; NC_002952.2.
DR AlphaFoldDB; Q6GGC7; -.
DR SMR; Q6GGC7; -.
DR GeneID; 66839763; -.
DR KEGG; sar:SAR1650; -.
DR HOGENOM; CLU_836378_0_0_9; -.
DR OMA; GIMDYYR; -.
DR OrthoDB; 827327at2; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01562; FloA; 1.
DR InterPro; IPR022853; FloA.
DR Pfam; PF12127; YdfA_immunity; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..329
FT /note="Flotillin-like protein FloA"
FT /id="PRO_0000232561"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ SEQUENCE 329 AA; 35181 MW; 8FCD431F8C92E02C CRC64;
MFSLSFIVIA VIIVVALLIL FSFVPIGLWI SALAAGVHVG IGTLVGMRLR RVSPRKVIAP
LIKAHKAGLA LTTNQLESHY LAGGNVDRVV DANIAAQRAD IDLPFERAAA IDLAGRDVLE
AVQMSVNPKV IETPFIAGVA MNGIEVKAKA RITVRANIAR LVGGAGEETI IARVGEGIVS
TIGSSKHHTE VLENPDNISK TVLSKGLDSG TAFEILSIDI ADVDISKNIG ADLQTEQALA
DKNIAQAKAE ERRAMAVATE QEMKARVQEM HAKVVEAESE VPLAMAEALR SGNISVKDYY
NLKNIEADTG MRNAINKRTD QSDDESPEH