ID   FLOA_STAES              Reviewed;         329 AA.
AC   Q8CSD1;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN   Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=SE_1260;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC       equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC       increase in number as cells age. Flotillins are thought to be important
CC       factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC       raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
CC   -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR   EMBL; AE015929; AAO04859.1; -; Genomic_DNA.
DR   RefSeq; NP_764815.1; NC_004461.1.
DR   RefSeq; WP_001830989.1; NZ_WBME01000008.1.
DR   AlphaFoldDB; Q8CSD1; -.
DR   SMR; Q8CSD1; -.
DR   STRING; 176280.SE_1260; -.
DR   EnsemblBacteria; AAO04859; AAO04859; SE_1260.
DR   GeneID; 50018624; -.
DR   KEGG; sep:SE_1260; -.
DR   PATRIC; fig|176280.10.peg.1228; -.
DR   eggNOG; COG4864; Bacteria.
DR   HOGENOM; CLU_836378_0_0_9; -.
DR   OMA; GIMDYYR; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01562; FloA; 1.
DR   InterPro; IPR022853; FloA.
DR   Pfam; PF12127; YdfA_immunity; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..329
FT                   /note="Flotillin-like protein FloA"
FT                   /id="PRO_0000232566"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ   SEQUENCE   329 AA;  35173 MW;  0008EF4BF2F31C5A CRC64;
     MFSIGFIIIA VIIVVALLIL FSFVPVGLWI SALAAGVHVG IGTLVGMRLR RVSPRKVIAP
     LIKAHKAGLN LTTNQLESHY LAGGNVDRVV DANIAAQRAD IDLPFERGAA IDLAGRDVLE
     AVQMSVNPKV IETPFIAGVA MNGIEVKAKA RITVRANIAR LVGGAGEETI IARVGEGIVS
     TIGSSEHHTE VLENPDNISK TVLSKGLDSG TAFEILSIDI ADVDISKNIG ADLQTEQALA
     DKNIAQAKAE ERRAMAVASE QEMKARVQEM RAKVVEAESE VPLAMAEALR SGNIGVKDYY
     NLKNIEADTG MRNAINKRTD QNDDESPQQ