FLOA_STAHJ
ID FLOA_STAHJ Reviewed; 328 AA.
AC Q4L6S3;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=SH1343;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC increase in number as cells age. Flotillins are thought to be important
CC factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR EMBL; AP006716; BAE04652.1; -; Genomic_DNA.
DR RefSeq; WP_011275639.1; NC_007168.1.
DR AlphaFoldDB; Q4L6S3; -.
DR SMR; Q4L6S3; -.
DR STRING; 279808.SH1343; -.
DR PRIDE; Q4L6S3; -.
DR EnsemblBacteria; BAE04652; BAE04652; SH1343.
DR KEGG; sha:SH1343; -.
DR eggNOG; COG4864; Bacteria.
DR HOGENOM; CLU_836378_0_0_9; -.
DR OMA; GIMDYYR; -.
DR OrthoDB; 827327at2; -.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01562; FloA; 1.
DR InterPro; IPR022853; FloA.
DR Pfam; PF12127; YdfA_immunity; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..328
FT /note="Flotillin-like protein FloA"
FT /id="PRO_0000232568"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ SEQUENCE 328 AA; 35030 MW; 587A411859FF5442 CRC64;
MFGLGIIVIA VIIVIALLVL FSFVPVGLWI SAIAAGVKVG IGTLVGMRLR RVSPRKVIGP
LIKAHKAGLN LTTNQLESHY LAGGNVDRVV DANIAAQRAD INLPFERGAA IDLAGRDVLE
AVQMSVNPKV IETPFITGVA MNGIEVKAKA RITVRANISR LVGGSGEETI IARVGEGIVS
TIGSSEHHTQ VLENPDNISK TVLSKGLDSG TAFEILSIDI ADVDIGKNIG ADLQTEQALA
DKNIAQAKAE ERRAMAVASE QEMKARVQEM RAKVVEAESE VPLAMAEALR EGNLGVKDYY
NLKNVEADTG MRNAINKRTE QNEDESPK