FLOA_STAS1
ID FLOA_STAS1 Reviewed; 327 AA.
AC Q49Y16;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=SSP1183;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC increase in number as cells age. Flotillins are thought to be important
CC factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC Membrane raft {ECO:0000255|HAMAP-Rule:MF_01562}; Single-pass membrane
CC protein {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR EMBL; AP008934; BAE18328.1; -; Genomic_DNA.
DR RefSeq; WP_011302997.1; NZ_MTGA01000038.1.
DR AlphaFoldDB; Q49Y16; -.
DR SMR; Q49Y16; -.
DR STRING; 342451.SSP1183; -.
DR EnsemblBacteria; BAE18328; BAE18328; SSP1183.
DR GeneID; 66867412; -.
DR KEGG; ssp:SSP1183; -.
DR eggNOG; COG4864; Bacteria.
DR HOGENOM; CLU_836378_0_0_9; -.
DR OMA; GIMDYYR; -.
DR OrthoDB; 827327at2; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01562; FloA; 1.
DR InterPro; IPR022853; FloA.
DR Pfam; PF12127; YdfA_immunity; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..327
FT /note="Flotillin-like protein FloA"
FT /id="PRO_0000232569"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT REGION 305..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 34976 MW; 3A8DD4049B4723E1 CRC64;
MIGLIIIVVI VLVALLLLFS FVPVGLWISA IAAGVKVGIG TLVGMRLRRV SPRKVISPLI
KAHKAGLHLT TNQLESHYLA GGNVDRVVDA NIAAQRADIN LPFERGAAID LAGRDVLEAV
QMSVNPKVIE TPFIAGVAMN GIEVKAKARI TVRANIARLV GGAGEETIIA RVGEGIVSTI
GSSEHHTQVL ENPDNISKTV LSKGLDSGTA FEILSIDIAD VDISKNIGAD LQTEQALADK
NIAQAKAEER RAMAVAQEQE MKAKVQEMRS KVVEAEAEVP LAMAEALRSG NLGVKDYYNL
KNVEADTGMR NSINQRTNQK DDESPDK