FLOA_THEP3
ID FLOA_THEP3 Reviewed; 329 AA.
AC B0K9H8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Flotillin-like protein FloA {ECO:0000255|HAMAP-Rule:MF_01562};
GN Name=floA {ECO:0000255|HAMAP-Rule:MF_01562}; OrderedLocusNames=Teth39_1136;
OS Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium
OS thermohydrosulfuricum).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=340099;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33223 / DSM 2355 / 39E;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J.,
RA Richardson P.;
RT "Complete sequence of Thermoanaerobacter pseudethanolicus 39E.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Found in functional membrane microdomains (FMM) that may be
CC equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and
CC increase in number as cells age. Flotillins are thought to be important
CC factors in membrane fluidity. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBUNIT: Homooligomerizes. {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01562};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01562}. Membrane
CC raft {ECO:0000255|HAMAP-Rule:MF_01562}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
CC -!- SIMILARITY: Belongs to the flotillin-like FloA family.
CC {ECO:0000255|HAMAP-Rule:MF_01562}.
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DR EMBL; CP000924; ABY94791.1; -; Genomic_DNA.
DR RefSeq; WP_009052352.1; NC_010321.1.
DR AlphaFoldDB; B0K9H8; -.
DR SMR; B0K9H8; -.
DR STRING; 340099.Teth39_1136; -.
DR EnsemblBacteria; ABY94791; ABY94791; Teth39_1136.
DR KEGG; tpd:Teth39_1136; -.
DR eggNOG; COG4864; Bacteria.
DR HOGENOM; CLU_836378_0_0_9; -.
DR OMA; GIMDYYR; -.
DR Proteomes; UP000002156; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01562; FloA; 1.
DR InterPro; IPR022853; FloA.
DR Pfam; PF12127; YdfA_immunity; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..329
FT /note="Flotillin-like protein FloA"
FT /id="PRO_1000199716"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01562"
SQ SEQUENCE 329 AA; 35763 MW; FBC5C518292D87CE CRC64;
MTEFIFLLVV IGLIFVFLSV ILSFIPLGLW ISALAAGVKI GIFTLVGMRL RRVPPDKIVK
PLIKAIKAGQ DVEINKLEAH YLAGGNVDKV IDALIAAQRA NISLEFERAA AIDLAGRDVL
HAVQMSVNPK VIETPVVAAV AKDGIEVKVK ARVTVRANID RLVGGAGEET IIARVGEGIV
TTVGSSNSHK EVLENPDSIS RTVLNKGLDA GTAFEILSID IADVDVGRNI GARLQIDQAE
ADKRIAQAKA EERRAMAVAR EQEMKAMVQE MRAKVVEAEA EVPKAMAEAL RTGKIGVMDY
YNMRNVIADT MMRESFSKLG QERQQEEKE