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FLOT1_ARATH
ID   FLOT1_ARATH             Reviewed;         470 AA.
AC   Q501E6;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Flotillin-like protein 1;
DE            Short=AtFLOT1;
DE   AltName: Full=Nodulin-like protein 1;
GN   Name=FLOT1; OrderedLocusNames=At5g25250; ORFNames=F21J6.108;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Cheuk R., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF Clones.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF Clones.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   IDENTIFICATION, AND SUBCELLULAR LOCATION.
RX   PubMed=15618420; DOI=10.1104/pp.104.053041;
RA   Borner G.H., Sherrier D.J., Weimar T., Michaelson L.V., Hawkins N.D.,
RA   Macaskill A., Napier J.A., Beale M.H., Lilley K.S., Dupree P.;
RT   "Analysis of detergent-resistant membranes in Arabidopsis. Evidence for
RT   plasma membrane lipid rafts.";
RL   Plant Physiol. 137:104-116(2005).
CC   -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC       functionally participating in formation of caveolae or caveolae-like
CC       vesicles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}. Membrane, caveola {ECO:0000269|PubMed:15618420}.
CC   -!- PTM: May be palmitoylated. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AC006259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED93417.1; -; Genomic_DNA.
DR   EMBL; BT022021; AAY25433.1; -; mRNA.
DR   EMBL; AK229271; BAF01135.1; -; mRNA.
DR   EMBL; BT026368; ABH04475.1; -; mRNA.
DR   RefSeq; NP_197907.1; NM_122434.3.
DR   AlphaFoldDB; Q501E6; -.
DR   SMR; Q501E6; -.
DR   BioGRID; 17871; 3.
DR   IntAct; Q501E6; 3.
DR   STRING; 3702.AT5G25250.1; -.
DR   PaxDb; Q501E6; -.
DR   PRIDE; Q501E6; -.
DR   ProteomicsDB; 230015; -.
DR   EnsemblPlants; AT5G25250.1; AT5G25250.1; AT5G25250.
DR   GeneID; 832596; -.
DR   Gramene; AT5G25250.1; AT5G25250.1; AT5G25250.
DR   KEGG; ath:AT5G25250; -.
DR   Araport; AT5G25250; -.
DR   TAIR; locus:2146965; AT5G25250.
DR   eggNOG; KOG2668; Eukaryota.
DR   HOGENOM; CLU_030844_1_1_1; -.
DR   InParanoid; Q501E6; -.
DR   OMA; QPKINVW; -.
DR   OrthoDB; 812555at2759; -.
DR   PhylomeDB; Q501E6; -.
DR   PRO; PR:Q501E6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q501E6; baseline and differential.
DR   Genevisible; Q501E6; AT.
DR   GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; IDA:TAIR.
DR   GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0044853; C:plasma membrane raft; IDA:TAIR.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0071456; P:cellular response to hypoxia; IEP:TAIR.
DR   GO; GO:0006897; P:endocytosis; IEP:TAIR.
DR   GO; GO:0010324; P:membrane invagination; IMP:TAIR.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR027705; Flotillin_fam.
DR   PANTHER; PTHR13806; PTHR13806; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome.
FT   CHAIN           1..470
FT                   /note="Flotillin-like protein 1"
FT                   /id="PRO_0000395209"
FT   COILED          305..354
FT                   /evidence="ECO:0000255"
FT   LIPID           35
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   470 AA;  52310 MW;  80DD6790B718FC3A CRC64;
     MFKVARASQY LAITGAGIED IKLSKKSWVF PWQSCTVFDV SPVNYTFKVQ AMSAEKLPFV
     LPAVFTIGPR VDDDDALILY ARLISPHDKD SNHVHELVEG VIEGETRVLA ASMTMEEIFK
     GTKEFKKEVF DKVQLELNQF GLVIYNANVK QLVDVPGHEY FSYLGQKTQM EAANQARIDV
     SEAKMKGEIG AKERTGLTLQ NAAKIDAESK IISMQRQGEG TKEEIKVRTE VKVFENQKEA
     DVAKANAELA MKKAAWTKDA QVAEVEATKA VALREAELQT QVEKMNALTR TEKLKAEFLS
     KASVEYETKV QEANWELYNK QKQAEAVLYE KQKQAEAQKA QADAAFYSKQ KEAEGLVALA
     SAQGTYLRTL LDAVQNDYSC LRDFLMINNG IYQEIAKTNA MAVRDLQPKI SVWNHGGEQG
     GGSGNAMKDI AGLYKMLPPV LDTVYEQTGM QPPAWIGTLR GAEPKQVTRS
 
 
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