FLOT1_BOVIN
ID FLOT1_BOVIN Reviewed; 427 AA.
AC Q08DN8;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Flotillin-1;
GN Name=FLOT1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC functionally participating in formation of caveolae or caveolae-like
CC vesicles. {ECO:0000250}.
CC -!- SUBUNIT: Heterooligomeric complex of flotillin-1 and flotillin-2 and
CC caveolin-1 and caveolin-2. Interacts with ECPAS. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75955};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:O75955}. Endosome
CC {ECO:0000250|UniProtKB:O75955}. Membrane, caveola
CC {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O08917}. Melanosome
CC {ECO:0000250|UniProtKB:O75955}. Membrane raft
CC {ECO:0000250|UniProtKB:O75955}. Note=Identified by mass spectrometry in
CC melanosome fractions from stage I to stage IV. Membrane-associated
CC protein of caveola. {ECO:0000250|UniProtKB:O08917,
CC ECO:0000250|UniProtKB:O75955}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000305}.
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DR EMBL; BC123642; AAI23643.1; -; mRNA.
DR RefSeq; NP_001070355.1; NM_001076887.1.
DR RefSeq; XP_005223719.1; XM_005223662.3.
DR RefSeq; XP_005223720.1; XM_005223663.3.
DR RefSeq; XP_005223721.1; XM_005223664.3.
DR AlphaFoldDB; Q08DN8; -.
DR STRING; 9913.ENSBTAP00000013135; -.
DR SwissPalm; Q08DN8; -.
DR PaxDb; Q08DN8; -.
DR PRIDE; Q08DN8; -.
DR Ensembl; ENSBTAT00000013135; ENSBTAP00000013135; ENSBTAG00000009960.
DR GeneID; 532573; -.
DR KEGG; bta:532573; -.
DR CTD; 10211; -.
DR VEuPathDB; HostDB:ENSBTAG00000009960; -.
DR VGNC; VGNC:29036; FLOT1.
DR eggNOG; KOG2668; Eukaryota.
DR GeneTree; ENSGT00560000077232; -.
DR HOGENOM; CLU_038134_1_0_1; -.
DR InParanoid; Q08DN8; -.
DR OMA; ERQYDSE; -.
DR OrthoDB; 812555at2759; -.
DR TreeFam; TF324879; -.
DR Reactome; R-BTA-5213460; RIPK1-mediated regulated necrosis.
DR Reactome; R-BTA-8980692; RHOA GTPase cycle.
DR Reactome; R-BTA-9013106; RHOC GTPase cycle.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000009960; Expressed in trachea and 106 other tissues.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0098691; C:dopaminergic synapse; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0016600; C:flotillin complex; IBA:GO_Central.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0001931; C:uropod; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0071360; P:cellular response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0033227; P:dsRNA transport; IEA:Ensembl.
DR GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0044854; P:plasma membrane raft assembly; IEA:Ensembl.
DR GO; GO:1901890; P:positive regulation of cell junction assembly; IBA:GO_Central.
DR GO; GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IBA:GO_Central.
DR GO; GO:0045807; P:positive regulation of endocytosis; IBA:GO_Central.
DR GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0048643; P:positive regulation of skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0032226; P:positive regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
DR GO; GO:0034141; P:positive regulation of toll-like receptor 3 signaling pathway; IEA:Ensembl.
DR GO; GO:0070528; P:protein kinase C signaling; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0051580; P:regulation of neurotransmitter uptake; IEA:Ensembl.
DR GO; GO:0002090; P:regulation of receptor internalization; IBA:GO_Central.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR031905; Flotillin_C.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806; PTHR13806; 1.
DR Pfam; PF01145; Band_7; 1.
DR Pfam; PF15975; Flot; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endosome; Membrane; Phosphoprotein; Reference proteome.
FT CHAIN 1..427
FT /note="Flotillin-1"
FT /id="PRO_0000262588"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75955"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75955"
FT MOD_RES 385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75955"
SQ SEQUENCE 427 AA; 47353 MW; 0A65D8313E085C19 CRC64;
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE
AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
EKSQLIMQAE AEAEAVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK
LPQVAEEISG PLTSANKITL VSSGSGAMGA AKVTGEVLDI LSRLPESVER LTGVSISQVN
HKPLRTA
