ID   FLOT1_MACMU             Reviewed;         427 AA.
AC   Q5TM70;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Flotillin-1;
GN   Name=FLOT1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15269276; DOI=10.1093/molbev/msh216;
RA   Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT   "Rhesus macaque class I duplicon structures, organization, and evolution
RT   within the alpha block of the major histocompatibility complex.";
RL   Mol. Biol. Evol. 21:2079-2091(2004).
CC   -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC       functionally participating in formation of caveolae or caveolae-like
CC       vesicles. {ECO:0000250}.
CC   -!- SUBUNIT: Heterooligomeric complex of flotillin-1 and flotillin-2 and
CC       caveolin-1 and caveolin-2. Interacts with ECPAS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75955};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:O75955}. Endosome
CC       {ECO:0000250|UniProtKB:O75955}. Membrane, caveola
CC       {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O08917}. Melanosome
CC       {ECO:0000250|UniProtKB:O75955}. Membrane raft
CC       {ECO:0000250|UniProtKB:O75955}. Note=Identified by mass spectrometry in
CC       melanosome fractions from stage I to stage IV. Membrane-associated
CC       protein of caveola. {ECO:0000250|UniProtKB:O08917,
CC       ECO:0000250|UniProtKB:O75955}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB128049; BAD69756.1; -; Genomic_DNA.
DR   RefSeq; NP_001098638.1; NM_001105168.1.
DR   RefSeq; XP_014991343.1; XM_015135857.1.
DR   AlphaFoldDB; Q5TM70; -.
DR   Ensembl; ENSMMUT00000019754; ENSMMUP00000018494; ENSMMUG00000014071.
DR   Ensembl; ENSMMUT00000109749; ENSMMUP00000077941; ENSMMUG00000014071.
DR   GeneID; 714175; -.
DR   KEGG; mcc:714175; -.
DR   CTD; 10211; -.
DR   VEuPathDB; HostDB:ENSMMUG00000014071; -.
DR   VGNC; VGNC:72674; FLOT1.
DR   GeneTree; ENSGT00560000077232; -.
DR   InParanoid; Q5TM70; -.
DR   OrthoDB; 812555at2759; -.
DR   Proteomes; UP000006718; Chromosome 4.
DR   Bgee; ENSMMUG00000014071; Expressed in superior frontal gyrus and 22 other tissues.
DR   ExpressionAtlas; Q5TM70; baseline.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0016600; C:flotillin complex; IBA:GO_Central.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:1901890; P:positive regulation of cell junction assembly; IBA:GO_Central.
DR   GO; GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IBA:GO_Central.
DR   GO; GO:0045807; P:positive regulation of endocytosis; IBA:GO_Central.
DR   GO; GO:0070528; P:protein kinase C signaling; IBA:GO_Central.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   GO; GO:0002090; P:regulation of receptor internalization; IBA:GO_Central.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR031905; Flotillin_C.
DR   InterPro; IPR027705; Flotillin_fam.
DR   PANTHER; PTHR13806; PTHR13806; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   Pfam; PF15975; Flot; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endosome; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..427
FT                   /note="Flotillin-1"
FT                   /id="PRO_0000262589"
FT   MOD_RES         19
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
FT   MOD_RES         385
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
FT   MOD_RES         387
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
SQ   SEQUENCE   427 AA;  47413 MW;  869D48573E0843E6 CRC64;
     MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG
     VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI
     YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE
     AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL
     QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
     EKSQLIMQAE AEAESVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK
     LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI LTRLPESVER LTGVSISQVN
     HKPLRTA