ID   FLOT1_PONAB             Reviewed;         427 AA.
AC   Q5RBL4;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Flotillin-1;
GN   Name=FLOT1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC       functionally participating in formation of caveolae or caveolae-like
CC       vesicles. {ECO:0000250}.
CC   -!- SUBUNIT: Heterooligomeric complex of flotillin-1 and flotillin-2 and
CC       caveolin-1 and caveolin-2. Interacts with ECPAS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75955};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:O75955}. Endosome
CC       {ECO:0000250|UniProtKB:O75955}. Membrane, caveola
CC       {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O08917}. Melanosome
CC       {ECO:0000250|UniProtKB:O75955}. Membrane raft
CC       {ECO:0000250|UniProtKB:O75955}. Note=Identified by mass spectrometry in
CC       melanosome fractions from stage I to stage IV (By similarity).
CC       Membrane-associated protein of caveola (By similarity).
CC       {ECO:0000250|UniProtKB:O08917, ECO:0000250|UniProtKB:O75955}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR858626; CAH90846.1; -; mRNA.
DR   RefSeq; NP_001125483.1; NM_001132011.1.
DR   AlphaFoldDB; Q5RBL4; -.
DR   STRING; 9601.ENSPPYP00000024633; -.
DR   GeneID; 100172392; -.
DR   KEGG; pon:100172392; -.
DR   CTD; 10211; -.
DR   eggNOG; KOG2668; Eukaryota.
DR   InParanoid; Q5RBL4; -.
DR   OrthoDB; 812555at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0016600; C:flotillin complex; IEA:UniProt.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR031905; Flotillin_C.
DR   InterPro; IPR027705; Flotillin_fam.
DR   PANTHER; PTHR13806; PTHR13806; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   Pfam; PF15975; Flot; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endosome; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..427
FT                   /note="Flotillin-1"
FT                   /id="PRO_0000262591"
FT   MOD_RES         19
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
FT   MOD_RES         385
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
FT   MOD_RES         387
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O75955"
SQ   SEQUENCE   427 AA;  47375 MW;  13F4462350F94F12 CRC64;
     MFFTCGSNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG
     VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI
     YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE
     AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL
     QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
     EKSQLIMQAE AEAESVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK
     LPQVAEEISG PLTSANKITL ASSGSGTMGA AKVTGEVLDI LTRLPESVER LTGVSISQVN
     HKPLRTA