FLOT2_ARATH
ID FLOT2_ARATH Reviewed; 463 AA.
AC Q4V3D6;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Flotillin-like protein 2;
DE AltName: Full=Nodulin-like protein 2;
GN Name=FLOT2; OrderedLocusNames=At5g25260; ORFNames=F21J6.109;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC functionally participating in formation of caveolae or caveolae-like
CC vesicles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}. Membrane, caveola {ECO:0000250}.
CC -!- PTM: May be palmitoylated. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000305}.
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DR EMBL; AC006259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93418.1; -; Genomic_DNA.
DR EMBL; BT023420; AAY56411.1; -; mRNA.
DR RefSeq; NP_197908.1; NM_122435.5.
DR AlphaFoldDB; Q4V3D6; -.
DR SMR; Q4V3D6; -.
DR BioGRID; 17872; 10.
DR IntAct; Q4V3D6; 10.
DR STRING; 3702.AT5G25260.1; -.
DR PaxDb; Q4V3D6; -.
DR PRIDE; Q4V3D6; -.
DR ProteomicsDB; 230037; -.
DR EnsemblPlants; AT5G25260.1; AT5G25260.1; AT5G25260.
DR GeneID; 832597; -.
DR Gramene; AT5G25260.1; AT5G25260.1; AT5G25260.
DR KEGG; ath:AT5G25260; -.
DR Araport; AT5G25260; -.
DR TAIR; locus:2146975; AT5G25260.
DR eggNOG; KOG2668; Eukaryota.
DR HOGENOM; CLU_030844_1_1_1; -.
DR InParanoid; Q4V3D6; -.
DR OMA; PHDKQSN; -.
DR OrthoDB; 812555at2759; -.
DR PhylomeDB; Q4V3D6; -.
DR PRO; PR:Q4V3D6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q4V3D6; baseline and differential.
DR Genevisible; Q4V3D6; AT.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0044853; C:plasma membrane raft; IDA:TAIR.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806; PTHR13806; 1.
DR Pfam; PF01145; Band_7; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..463
FT /note="Flotillin-like protein 2"
FT /id="PRO_0000395210"
FT COILED 305..354
FT /evidence="ECO:0000255"
FT LIPID 35
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 463 AA; 51419 MW; 1A28FDB241A35EBD CRC64;
MFKVARASQY LAITGGGIED IKLSKKSWVF PWQRCTVFDV SPVNYTFKVQ AMSAEKLPFV
LPAVFTIGPR VDDTEALILY ARLISPHDKQ SNHVNELVEG VIEGETRVLA ASMTMEEIFK
GTKEFKKEVF DKVQLELDQF GLVIYNANVK QLVDVPGHEY FSYLGQKTQM EAANQARIDV
AEAKMKGEIG AKERTGLTLQ NAAKIDAESK IISMQRQGEG TKAEIKVKTE VKVFENQKEA
DVAKANSELA MKKAAWTKDA KVAEVEATKA VALREAELQT QVEKMNALTR TEKLKAEFLS
KASVEYETKV QEANWELYNK QKQAEAVLYE KQKQAEAQKA EADATFYSKQ KEAEGLVALA
SAQGTYLRTL LDAVQNDYSC LRDFLMINNG TYQEIAKTNA LAVRDLQPKI SVWNHGGEQG
IGGASGSGMK DIAGLYKMLP PVLDTVYEQT GMQPPAWIGT LSK
