FLOT3_ARATH
ID FLOT3_ARATH Reviewed; 479 AA.
AC Q9LV90; Q0WPP0; Q8LES6;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Flotillin-like protein 3;
DE AltName: Full=Nodulin-like protein 3;
GN Name=FLOT3; OrderedLocusNames=At5g64870; ORFNames=MXK3.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC functionally participating in formation of caveolae or caveolae-like
CC vesicles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}. Membrane, caveola {ECO:0000250}.
CC -!- PTM: May be palmitoylated. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000305}.
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DR EMBL; AB019236; BAA97299.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97963.1; -; Genomic_DNA.
DR EMBL; AY085257; AAM62489.1; -; mRNA.
DR EMBL; AK229023; BAF00909.1; -; mRNA.
DR EMBL; BT029217; ABJ17152.1; -; mRNA.
DR RefSeq; NP_201292.1; NM_125885.3.
DR AlphaFoldDB; Q9LV90; -.
DR BioGRID; 21852; 7.
DR IntAct; Q9LV90; 7.
DR STRING; 3702.AT5G64870.1; -.
DR PaxDb; Q9LV90; -.
DR PRIDE; Q9LV90; -.
DR ProteomicsDB; 230033; -.
DR EnsemblPlants; AT5G64870.1; AT5G64870.1; AT5G64870.
DR GeneID; 836610; -.
DR Gramene; AT5G64870.1; AT5G64870.1; AT5G64870.
DR KEGG; ath:AT5G64870; -.
DR Araport; AT5G64870; -.
DR TAIR; locus:2177729; AT5G64870.
DR eggNOG; KOG2668; Eukaryota.
DR HOGENOM; CLU_030844_1_1_1; -.
DR InParanoid; Q9LV90; -.
DR OMA; NHGGAEQ; -.
DR OrthoDB; 812555at2759; -.
DR PhylomeDB; Q9LV90; -.
DR PRO; PR:Q9LV90; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LV90; baseline and differential.
DR Genevisible; Q9LV90; AT.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0044853; C:plasma membrane raft; IDA:TAIR.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806; PTHR13806; 1.
DR Pfam; PF01145; Band_7; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..479
FT /note="Flotillin-like protein 3"
FT /id="PRO_0000395211"
FT COILED 227..251
FT /evidence="ECO:0000255"
FT COILED 306..326
FT /evidence="ECO:0000255"
FT LIPID 36
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CONFLICT 7
FT /note="K -> Q (in Ref. 4; BAF00909)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="G -> V (in Ref. 3; AAM62489)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 479 AA; 52833 MW; AC032D9A212A3BFA CRC64;
MSYRVAKASQ YLAITGGGIT DIKLAKKSWV FPWQSCTVFD VSPVNYTFEV QAMSSEKLPF
VIPAVFTIGP RVDDPHALLL YAMLMSQHDK HSNHVNELVQ GVIEGETRVL VASMTMEEVF
KGTKEFKKEV FDKVQLELNQ FGLVIYNANV KQLVDVPGHE YFSYLGQKTQ MEAANQAKID
VAEAKMKGEV GAKERTGLTI QNAAKIDAES KIISTQRLGE GTKEEIKVKT EVKVFQNEKE
ALVAKADAAL AIQKAALSQN SRVAEVEAAK AVALREAELQ TKVEKMNALT RTEKLKAEFL
SKASVEYETK VQEANWELYN KQKQAEAVLY EKQKQAEATK AAADAAFYSK QKDAEGLVAM
ADAQGTYLKT LLGAVNNDYS AMRDFLMINN GIYQDIAKTN AVAIRDLQPK ISVWNHGGAE
QGMNGGGKAT MNDIAGLYKM LPPVLDTVYE QTGMQPPAWI GTLRGAEPKQ SLHAQQHRG
