ID   FLOT6_MEDTR             Reviewed;         472 AA.
AC   D2XNR2;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Flotillin-like protein 6;
GN   Name=FLOT6;
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX   NCBI_TaxID=3880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=20018678; DOI=10.1073/pnas.0910081107;
RA   Haney C.H., Long S.R.;
RT   "Plant flotillins are required for infection by nitrogen-fixing bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:478-483(2010).
CC   -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC       functionally participating in formation of caveolae or caveolae-like
CC       vesicles (By similarity). May be involved in nodule formation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}. Membrane, caveola {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Very low occasional expression in roots and
CC       nodules. {ECO:0000269|PubMed:20018678}.
CC   -!- PTM: May be palmitoylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; GU224282; ADA83098.1; -; mRNA.
DR   RefSeq; XP_003591134.1; XM_003591086.1.
DR   AlphaFoldDB; D2XNR2; -.
DR   STRING; 3880.AES61385; -.
DR   EnsemblPlants; AES61385; AES61385; MTR_1g083190.
DR   GeneID; 11408733; -.
DR   Gramene; AES61385; AES61385; MTR_1g083190.
DR   eggNOG; KOG2668; Eukaryota.
DR   HOGENOM; CLU_030844_1_1_1; -.
DR   OMA; NHGGAEQ; -.
DR   OrthoDB; 812555at2759; -.
DR   ExpressionAtlas; D2XNR2; differential.
DR   GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR   GO; GO:0009877; P:nodulation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR027705; Flotillin_fam.
DR   PANTHER; PTHR13806; PTHR13806; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Lipoprotein; Membrane; Nodulation; Palmitate.
FT   CHAIN           1..472
FT                   /note="Flotillin-like protein 6"
FT                   /id="PRO_0000395208"
FT   COILED          237..327
FT                   /evidence="ECO:0000255"
FT   LIPID           37
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   472 AA;  52387 MW;  A773BDA96F18E3FA CRC64;
     MKIYRVAKAS EYLVITGILI KDIKLAKKAW ILPGQSCSVL DLSPVNYTFE VQAMSAEKLP
     FVLPAVFTIG PRVDDKESLL KYAKLISPHA RHSNHVNELV QGIIEGETRV LAASMTMEEV
     FRGTKQFKQE VFDKVQLELN QFGLLIYNAN VKQLVDVRGH EYFSYLGQKT QMEAKNQARV
     DVAEAKMKGE IGSKLREGQT LQNAAKIDAE TKVIAMQRAG EGEKEGIKVR TEVKVFENQR
     EAEVAQANSE LAKKKAAWTK AAQVAEVEAK KAVKLREAEL QGEVERMNAL TTTEKLKAEF
     LSKASVQYET KVQEANWELY KKQKEAEAIL YEKKAEAEAQ KASADATFYA SKQAAEAELY
     AKKKEAEGIV TVGQAQGVYV SKLLNALGND YTAVRDYLMI NGGMFQEIAK INAEAIRGLE
     PKISIWTNGG EAGGMKEVAG VYKMLPPLFK TVHEQTGMLP PAWMGVLPDK NS