FLOWR_DROAN
ID FLOWR_DROAN Reviewed; 195 AA.
AC B3M9W1;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Calcium channel flower {ECO:0000250|UniProtKB:Q95T12};
GN Name=flower {ECO:0000250|UniProtKB:Q95T12}; ORFNames=GF10375;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1] {ECO:0000312|EMBL:EDV40152.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV40152.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: A calcium channel that regulates synaptic endocytosis and
CC hence couples exo- with endocytosis. Required in the nervous system and
CC necessary in photoreceptor cells (By similarity).
CC {ECO:0000250|UniProtKB:Q95T12}.
CC -!- SUBUNIT: Homomultimer. {ECO:0000250|UniProtKB:Q95T12}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250|UniProtKB:Q95T12}; Multi-pass membrane
CC protein {ECO:0000250|UniProtKB:Q95T12}. Note=Upon fusion of the
CC synaptic vesicle with the presynaptic membrane, protein is present in
CC the periactive zones, where endocytosis is known to occur.
CC {ECO:0000250|UniProtKB:Q95T12}.
CC -!- SIMILARITY: Belongs to the calcium channel flower family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDV40152.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH902618; EDV40152.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001957346.2; XM_001957310.2.
DR AlphaFoldDB; B3M9W1; -.
DR EnsemblMetazoa; FBtr0115075; FBpp0113567; FBgn0087416.
DR GeneID; 6493245; -.
DR KEGG; dan:6493245; -.
DR eggNOG; KOG4085; Eukaryota.
DR InParanoid; B3M9W1; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030285; C:integral component of synaptic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0046530; P:photoreceptor cell differentiation; ISS:UniProtKB.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
DR InterPro; IPR019365; TVP18/Ca-channel_flower.
DR PANTHER; PTHR13314; PTHR13314; 1.
DR Pfam; PF10233; Cg6151-P; 1.
DR SMART; SM01077; Cg6151-P; 1.
PE 3: Inferred from homology;
KW Calcium; Calcium channel; Calcium transport; Cytoplasmic vesicle;
KW Endocytosis; Ion channel; Ion transport; Membrane; Reference proteome;
KW Synapse; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..195
FT /note="Calcium channel flower"
FT /id="PRO_0000389231"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT SITE 79
FT /note="Calcium ion selectivity"
FT /evidence="ECO:0000250|UniProtKB:Q95T12"
SQ SEQUENCE 195 AA; 20756 MW; 2D969F776C4C2EE6 CRC64;
MSFAEKITGL LARPNQQDPV GPEQPWYLKY GSRLLGIVAA FFAILFGLWN VISILTLNVG
CLVAGIIQMV AGFVVMLLEA PCCFVCIEKV NDIADKVDSK PMYFRAGLYC AMAVPPIFMC
FGLASLFGSG LIFATGVIYG MMALGKKASA EDMRAAAQQS YAGNATPQTT NDRAGIVNNA
QPFSFTGAVG TDSNV
