ID   FLOWR_DROGR             Reviewed;         196 AA.
AC   B4J043;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Calcium channel flower {ECO:0000250|UniProtKB:Q95T12};
GN   Name=flower {ECO:0000250|UniProtKB:Q95T12}; ORFNames=GH14474;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDV97836.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV97836.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: A calcium channel that regulates synaptic endocytosis and
CC       hence couples exo- with endocytosis. Required in the nervous system and
CC       necessary in photoreceptor cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q95T12}.
CC   -!- SUBUNIT: Homomultimer. {ECO:0000250|UniProtKB:Q95T12}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250|UniProtKB:Q95T12}; Multi-pass membrane
CC       protein {ECO:0000250|UniProtKB:Q95T12}. Note=Upon fusion of the
CC       synaptic vesicle with the presynaptic membrane, protein is present in
CC       the periactive zones, where endocytosis is known to occur.
CC       {ECO:0000250|UniProtKB:Q95T12}.
CC   -!- SIMILARITY: Belongs to the calcium channel flower family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDV97836.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH916366; EDV97836.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001985488.1; XM_001985452.1.
DR   AlphaFoldDB; B4J043; -.
DR   STRING; 7222.FBpp0148380; -.
DR   EnsemblMetazoa; FBtr0459077; FBpp0409538; FBgn0121950.
DR   eggNOG; KOG4085; Eukaryota.
DR   InParanoid; B4J043; -.
DR   OrthoDB; 1295049at2759; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030285; C:integral component of synaptic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0044214; C:spanning component of plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa.
DR   GO; GO:0150008; P:bulk synaptic vesicle endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0035212; P:cell competition in a multicellular organism; IEA:EnsemblMetazoa.
DR   GO; GO:0150007; P:clathrin-dependent synaptic vesicle endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0046530; P:photoreceptor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:EnsemblMetazoa.
DR   GO; GO:0099533; P:positive regulation of presynaptic cytosolic calcium concentration; IEA:EnsemblMetazoa.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
DR   InterPro; IPR019365; TVP18/Ca-channel_flower.
DR   PANTHER; PTHR13314; PTHR13314; 1.
DR   Pfam; PF10233; Cg6151-P; 1.
DR   SMART; SM01077; Cg6151-P; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium channel; Calcium transport; Cytoplasmic vesicle;
KW   Endocytosis; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Synapse; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..196
FT                   /note="Calcium channel flower"
FT                   /id="PRO_0000389233"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   SITE            79
FT                   /note="Calcium ion selectivity"
FT                   /evidence="ECO:0000250|UniProtKB:Q95T12"
SQ   SEQUENCE   196 AA;  20338 MW;  1A0E07E452A32795 CRC64;
     MSFAEKITGL LARPNQDPAG GPEAPWYLKY GSRVLGIVAA FFAILFGLWN VLSIIGLSVS
     CLVAGIIQML AGFVVMALEA PCCFVCIEQV GSVADKVDAK PMYFRAGLYC AMAVPPIFMC
     FGLASLFGSG LIFATGAVYG MMALGKKASA TDMRAAAQQS GYGGNATTST TNDRAGIVNN
     AQPFSFTGAV GTDSNV