ID   FLOWR_DROSI             Reviewed;         194 AA.
AC   B4QLP9;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Calcium channel flower {ECO:0000250|UniProtKB:Q95T12};
GN   Name=flower {ECO:0000250|UniProtKB:Q95T12}; ORFNames=GD12536;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:EDX10598.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: A calcium channel that regulates synaptic endocytosis and
CC       hence couples exo- with endocytosis. Required in the nervous system and
CC       necessary in photoreceptor cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q95T12}.
CC   -!- SUBUNIT: Homomultimer. {ECO:0000250|UniProtKB:Q95T12}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250|UniProtKB:Q95T12}; Multi-pass membrane
CC       protein {ECO:0000250|UniProtKB:Q95T12}. Note=Upon fusion of the
CC       synaptic vesicle with the presynaptic membrane, protein is present in
CC       the periactive zones, where endocytosis is known to occur.
CC       {ECO:0000250|UniProtKB:Q95T12}.
CC   -!- SIMILARITY: Belongs to the calcium channel flower family.
CC       {ECO:0000305}.
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DR   EMBL; CM000363; EDX10598.1; -; Genomic_DNA.
DR   RefSeq; XP_002085013.1; XM_002084977.2.
DR   AlphaFoldDB; B4QLP9; -.
DR   STRING; 7240.B4QLP9; -.
DR   EnsemblMetazoa; FBtr0212446; FBpp0210938; FBgn0184264.
DR   GeneID; 6738200; -.
DR   HOGENOM; CLU_108196_0_0_1; -.
DR   OMA; CEAPCCC; -.
DR   PhylomeDB; B4QLP9; -.
DR   Proteomes; UP000000304; Chromosome 3l.
DR   Bgee; FBgn0184264; Expressed in embryo and 3 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030285; C:integral component of synaptic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0044214; C:spanning component of plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa.
DR   GO; GO:0150008; P:bulk synaptic vesicle endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0035212; P:cell competition in a multicellular organism; IEA:EnsemblMetazoa.
DR   GO; GO:0150007; P:clathrin-dependent synaptic vesicle endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0046530; P:photoreceptor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:EnsemblMetazoa.
DR   GO; GO:0099533; P:positive regulation of presynaptic cytosolic calcium concentration; IEA:EnsemblMetazoa.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
DR   InterPro; IPR019365; TVP18/Ca-channel_flower.
DR   PANTHER; PTHR13314; PTHR13314; 1.
DR   Pfam; PF10233; Cg6151-P; 1.
DR   SMART; SM01077; Cg6151-P; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium channel; Calcium transport; Cytoplasmic vesicle;
KW   Endocytosis; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Synapse; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..194
FT                   /note="Calcium channel flower"
FT                   /id="PRO_0000389238"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   SITE            79
FT                   /note="Calcium ion selectivity"
FT                   /evidence="ECO:0000250|UniProtKB:Q95T12"
SQ   SEQUENCE   194 AA;  20707 MW;  B1B44DE5B24DCC97 CRC64;
     MSFAEKITGL LARPNQQDPI GPEQPWYLKY GSRWLGIVAA FFAILFGLWN VFSIITLSVS
     CLVAGIIQMV AGFVVMLLEA PCCFVCFEQV NVIADKVDSK PLYFRAGLYI AMAIPPIILC
     FGLASLFGSG LIFGTGVVYG MMALGKKASA EDMRAAAQQT FGGNTPAQTN DRAGIVNNAQ
     PFSFTGAVGT DSNV