FLOWR_MOUSE
ID FLOWR_MOUSE Reviewed; 171 AA.
AC Q8BG21; A2AR22; A2AR23; Q8C9W0; Q8CC30; Q9CX69;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Calcium channel flower homolog;
DE AltName: Full=Calcium channel flower domain-containing protein 1;
GN Name=Cacfd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Stomach, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BG21-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BG21-2; Sequence=VSP_012998, VSP_012999;
CC Name=3;
CC IsoId=Q8BG21-3; Sequence=VSP_013000;
CC -!- SIMILARITY: Belongs to the calcium channel flower family.
CC {ECO:0000305}.
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DR EMBL; AK020041; BAB31977.1; -; mRNA.
DR EMBL; AK034046; BAC28559.1; -; mRNA.
DR EMBL; AK039867; BAC30468.1; -; mRNA.
DR EMBL; AK040379; BAC30577.1; -; mRNA.
DR EMBL; AK052562; BAC35040.1; -; mRNA.
DR EMBL; AL845266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38086.1; -. [Q8BG21-1]
DR CCDS; CCDS57160.1; -. [Q8BG21-2]
DR CCDS; CCDS57161.1; -. [Q8BG21-3]
DR RefSeq; NP_001230168.1; NM_001243239.1. [Q8BG21-2]
DR RefSeq; NP_001230169.1; NM_001243240.1. [Q8BG21-3]
DR RefSeq; NP_084138.1; NM_029862.4. [Q8BG21-1]
DR AlphaFoldDB; Q8BG21; -.
DR STRING; 10090.ENSMUSP00000109639; -.
DR PhosphoSitePlus; Q8BG21; -.
DR SwissPalm; Q8BG21; -.
DR MaxQB; Q8BG21; -.
DR PaxDb; Q8BG21; -.
DR PRIDE; Q8BG21; -.
DR ProteomicsDB; 272999; -. [Q8BG21-1]
DR Antibodypedia; 3031; 93 antibodies from 17 providers.
DR Ensembl; ENSMUST00000114004; ENSMUSP00000109637; ENSMUSG00000015488. [Q8BG21-3]
DR Ensembl; ENSMUST00000114005; ENSMUSP00000109638; ENSMUSG00000015488. [Q8BG21-2]
DR Ensembl; ENSMUST00000114006; ENSMUSP00000109639; ENSMUSG00000015488. [Q8BG21-1]
DR Ensembl; ENSMUST00000114007; ENSMUSP00000109640; ENSMUSG00000015488. [Q8BG21-1]
DR GeneID; 381356; -.
DR KEGG; mmu:381356; -.
DR UCSC; uc008iwq.2; mouse. [Q8BG21-2]
DR UCSC; uc008iws.2; mouse. [Q8BG21-1]
DR CTD; 11094; -.
DR MGI; MGI:1924317; Cacfd1.
DR VEuPathDB; HostDB:ENSMUSG00000015488; -.
DR eggNOG; KOG4085; Eukaryota.
DR GeneTree; ENSGT00390000000529; -.
DR HOGENOM; CLU_108196_2_0_1; -.
DR InParanoid; Q8BG21; -.
DR OMA; MIMNAFV; -.
DR OrthoDB; 1295049at2759; -.
DR PhylomeDB; Q8BG21; -.
DR TreeFam; TF105629; -.
DR BioGRID-ORCS; 381356; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Cacfd1; mouse.
DR PRO; PR:Q8BG21; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BG21; protein.
DR Bgee; ENSMUSG00000015488; Expressed in metanephric mesenchyme and 247 other tissues.
DR ExpressionAtlas; Q8BG21; baseline and differential.
DR Genevisible; Q8BG21; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR019365; TVP18/Ca-channel_flower.
DR PANTHER; PTHR13314; PTHR13314; 1.
DR Pfam; PF10233; Cg6151-P; 1.
DR SMART; SM01077; Cg6151-P; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..171
FT /note="Calcium channel flower homolog"
FT /id="PRO_0000089672"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 107..171
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013000"
FT VAR_SEQ 107..128
FT /note="MAIVPIVMSLTLTTLLGNAIAF -> HGEALRGAWPDVRLPNRNTISL (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_012998"
FT VAR_SEQ 129..171
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_012999"
SQ SEQUENCE 171 AA; 18343 MW; D18D0A2BCCB6AA67 CRC64;
MSGSGAAGAA AGPAPPAQEE GMTWWYRWLC RLAGVLGAVS CAISGLFNCV TIHPLNIAAG
VWMIMNAFIL LLCEAPFCCQ FVEFANTVAE KVDRLRSWQK AVFYCGMAIV PIVMSLTLTT
LLGNAIAFAT GVLYGLSALG KKGDAISYAR IQQQRQQADE EKLAETFEGE L
