FLP05_CAEEL
ID FLP05_CAEEL Reviewed; 92 AA.
AC O61466;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2013, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=FMRFamide-like neuropeptides 5;
DE Contains:
DE RecName: Full=APKPKFIRF-amide;
DE Contains:
DE RecName: Full=AGAKFIRF-amide;
DE Contains:
DE RecName: Full=GAKFIRF-amide;
DE Flags: Precursor;
GN Name=flp-5 {ECO:0000312|EMBL:AAC08942.1}; ORFNames=C03G5.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC08942.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:AAC08942.1};
RX PubMed=9685599; DOI=10.1016/s0169-328x(98)00106-5;
RA Nelson L.S., Kim K., Memmott J.E., Li C.;
RT "FMRFamide-related gene family in the nematode, Caenorhabditis elegans.";
RL Brain Res. Mol. Brain Res. 58:103-111(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 85-91, AND AMIDATION AT PHE-91.
RC STRAIN=Bristol N2 {ECO:0000269|PubMed:16061202};
RX PubMed=16061202; DOI=10.1016/j.bbrc.2005.07.044;
RA Husson S.J., Clynen E., Baggerman G., De Loof A., Schoofs L.;
RT "Discovering neuropeptides in Caenorhabditis elegans by two dimensional
RT liquid chromatography and mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 335:76-86(2005).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15236235; DOI=10.1002/cne.20189;
RA Kim K., Li C.;
RT "Expression and regulation of an FMRFamide-related neuropeptide gene family
RT in Caenorhabditis elegans.";
RL J. Comp. Neurol. 475:540-550(2004).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=16187307; DOI=10.1002/neu.20201;
RA Papaioannou S., Marsden D., Franks C.J., Walker R.J., Holden-Dye L.;
RT "Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous
RT system of Caenorhabditis elegans.";
RL J. Neurobiol. 65:304-319(2005).
CC -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC GAKFIRF-amide has an excitatory effect on dissected pharyngeal myogenic
CC muscle system. {ECO:0000269|PubMed:16187307}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Each flp gene is expressed in a distinct set of
CC neurons. Flp-5 is expressed in the ASE sensory neurons, the 14 and M4
CC cholinergic pharyngeal motoneurons, and the PVT and RMG neurons. It is
CC weakly expressed in the PB and 12 neurons. Also expressed in pharyngeal
CC muscle. {ECO:0000269|PubMed:15236235}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the comma stage of embryogenesis,
CC during all larval stages, and in adults. {ECO:0000269|PubMed:15236235,
CC ECO:0000269|PubMed:9685599}.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC08942.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF042391; AAC08942.1; ALT_INIT; mRNA.
DR EMBL; FO080313; CCD62795.2; -; Genomic_DNA.
DR PIR; T42412; T42412.
DR RefSeq; NP_509445.2; NM_077044.6.
DR AlphaFoldDB; O61466; -.
DR BioGRID; 46025; 3.
DR STRING; 6239.C03G5.7.1; -.
DR EPD; O61466; -.
DR PaxDb; O61466; -.
DR EnsemblMetazoa; C03G5.7.1; C03G5.7.1; WBGene00001448.
DR EnsemblMetazoa; C03G5.7.2; C03G5.7.2; WBGene00001448.
DR UCSC; C03G5.7; c. elegans.
DR WormBase; C03G5.7; CE48316; WBGene00001448; flp-5.
DR eggNOG; ENOG502THZ9; Eukaryota.
DR HOGENOM; CLU_166337_0_0_1; -.
DR InParanoid; O61466; -.
DR OMA; FQCVSAQ; -.
DR OrthoDB; 1564131at2759; -.
DR PRO; PR:O61466; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001448; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR002544; FMRFamid-related_peptide-like.
DR Pfam; PF01581; FARP; 3.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted.
FT PROPEP 1..41
FT /id="PRO_0000312043"
FT PEPTIDE 43..51
FT /note="APKPKFIRF-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000312044"
FT PEPTIDE 54..61
FT /note="AGAKFIRF-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000312045"
FT PROPEP 64..82
FT /id="PRO_0000312046"
FT PEPTIDE 85..91
FT /note="GAKFIRF-amide"
FT /id="PRO_0000312047"
FT MOD_RES 51
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 61
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 91
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16061202"
SQ SEQUENCE 92 AA; 10466 MW; DF9260173F359DBC CRC64;
MSSRSTTIAF LFIATLLVFQ CVSAQSSAED ADYLEKYQRI ARAPKPKFIR FGRAGAKFIR
FGRSRNTWED GYASPSVNEL YVKRGAKFIR FG
