ID   FLP16_CAEBR             Reviewed;          95 AA.
AC   A8WTF8;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 3.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=FMRFamide-like neuropeptides 16 {ECO:0000250|UniProtKB:Q7YX32};
DE   Contains:
DE     RecName: Full=AQTFVRF-amide 1 {ECO:0000250|UniProtKB:Q7YX32};
DE   Contains:
DE     RecName: Full=AQTFVRF-amide 2 {ECO:0000250|UniProtKB:Q7YX32};
DE   Contains:
DE     RecName: Full=GQTFVRF-amide {ECO:0000250|UniProtKB:Q7YX32};
DE   Flags: Precursor;
GN   Name=flp-16; ORFNames=CBG02820;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC       AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic
CC       muscle system (By similarity). {ECO:0000250|UniProtKB:Q7YX32}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q7YX32}.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE601438; CAP23770.3; -; Genomic_DNA.
DR   RefSeq; XP_002631056.1; XM_002631010.1.
DR   AlphaFoldDB; A8WTF8; -.
DR   SMR; A8WTF8; -.
DR   STRING; 6238.CBG02820; -.
DR   EnsemblMetazoa; CBG02820a.1; CBG02820a.1; WBGene00025799.
DR   GeneID; 8572570; -.
DR   KEGG; cbr:CBG_02820; -.
DR   CTD; 8572570; -.
DR   WormBase; CBG02820a; CBP21170; WBGene00025799; Cbr-flp-16.
DR   eggNOG; ENOG502TI12; Eukaryota.
DR   HOGENOM; CLU_2456864_0_0_1; -.
DR   InParanoid; A8WTF8; -.
DR   OMA; VDYASQY; -.
DR   OrthoDB; 1584688at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0071244; P:cellular response to carbon dioxide; IEA:EnsemblMetazoa.
DR   GO; GO:1903745; P:negative regulation of pharyngeal pumping; IEA:EnsemblMetazoa.
DR   GO; GO:0045988; P:negative regulation of striated muscle contraction; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..58
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
FT                   /id="PRO_0000396646"
FT   PEPTIDE         61..67
FT                   /note="AQTFVRF-amide 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
FT                   /id="PRO_0000396647"
FT   PEPTIDE         71..77
FT                   /note="AQTFVRF-amide 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
FT                   /id="PRO_0000396648"
FT   PEPTIDE         81..87
FT                   /note="GQTFVRF-amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
FT                   /id="PRO_0000396649"
FT   PROPEP          90..95
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
FT                   /id="PRO_0000396650"
FT   MOD_RES         67
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
FT   MOD_RES         77
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
FT   MOD_RES         87
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q7YX32"
SQ   SEQUENCE   95 AA;  10454 MW;  703353AC814DA23B CRC64;
     MSLSGFEFSS IIAVLLLLIQ LSSAAVLPVD YASQYGVASA DEMTALPEEG SLFAERPAKR
     AQTFVRFGKR AQTFVRFGKR GQTFVRFGRS APFEQ