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FLP16_CAEEL
ID   FLP16_CAEEL             Reviewed;          92 AA.
AC   Q7YX32;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=FMRFamide-like neuropeptides 16;
DE   Contains:
DE     RecName: Full=AQTFVRF-amide 1;
DE   Contains:
DE     RecName: Full=AQTFVRF-amide 2;
DE   Contains:
DE     RecName: Full=GQTFVRF-amide;
DE   Flags: Precursor;
GN   Name=flp-16 {ECO:0000312|EMBL:CAE17795.1}; ORFNames=F15D4.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1] {ECO:0000312|EMBL:CAE17795.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|EMBL:CAE17795.1};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 58-64; 68-74 AND 78-84, AND AMIDATION AT PHE-64; PHE-74
RP   AND PHE-84.
RC   STRAIN=Bristol N2 {ECO:0000269|PubMed:16061202};
RX   PubMed=16061202; DOI=10.1016/j.bbrc.2005.07.044;
RA   Husson S.J., Clynen E., Baggerman G., De Loof A., Schoofs L.;
RT   "Discovering neuropeptides in Caenorhabditis elegans by two dimensional
RT   liquid chromatography and mass spectrometry.";
RL   Biochem. Biophys. Res. Commun. 335:76-86(2005).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=16187307; DOI=10.1002/neu.20201;
RA   Papaioannou S., Marsden D., Franks C.J., Walker R.J., Holden-Dye L.;
RT   "Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous
RT   system of Caenorhabditis elegans.";
RL   J. Neurobiol. 65:304-319(2005).
CC   -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC       AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic
CC       muscle system. {ECO:0000269|PubMed:16187307}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Each flp gene is expressed in a distinct set of
CC       neurons. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000255}.
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DR   EMBL; Z80344; CAE17795.1; -; Genomic_DNA.
DR   RefSeq; NP_001022091.1; NM_001026920.4.
DR   AlphaFoldDB; Q7YX32; -.
DR   STRING; 6239.F15D4.8; -.
DR   PaxDb; Q7YX32; -.
DR   EnsemblMetazoa; F15D4.8.1; F15D4.8.1; WBGene00001459.
DR   GeneID; 174967; -.
DR   UCSC; F15D4.8; c. elegans.
DR   CTD; 174967; -.
DR   WormBase; F15D4.8; CE34815; WBGene00001459; flp-16.
DR   eggNOG; ENOG502TI12; Eukaryota.
DR   HOGENOM; CLU_2456864_0_0_1; -.
DR   InParanoid; Q7YX32; -.
DR   OMA; VDYASQY; -.
DR   OrthoDB; 1584688at2759; -.
DR   PRO; PR:Q7YX32; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00001459; Expressed in larva and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
DR   GO; GO:0071244; P:cellular response to carbon dioxide; IMP:UniProtKB.
DR   GO; GO:1903745; P:negative regulation of pharyngeal pumping; IMP:UniProtKB.
DR   GO; GO:0045988; P:negative regulation of striated muscle contraction; IDA:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; TAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..55
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000312075"
FT   PEPTIDE         58..64
FT                   /note="AQTFVRF-amide 1"
FT                   /evidence="ECO:0000269|PubMed:16061202"
FT                   /id="PRO_0000312076"
FT   PEPTIDE         68..74
FT                   /note="AQTFVRF-amide 2"
FT                   /evidence="ECO:0000269|PubMed:16061202"
FT                   /id="PRO_0000312077"
FT   PEPTIDE         78..84
FT                   /note="GQTFVRF-amide"
FT                   /evidence="ECO:0000269|PubMed:16061202"
FT                   /id="PRO_0000312078"
FT   PROPEP          87..92
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000312079"
FT   MOD_RES         64
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:16061202"
FT   MOD_RES         74
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:16061202"
FT   MOD_RES         84
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:16061202"
SQ   SEQUENCE   92 AA;  10270 MW;  7DAE850F89E539E9 CRC64;
     MNFSGFEFSS IVAFFLLILQ LSTAAVLPAD YAYGVADEMS ALPDSGSLFA EQRPSKRAQT
     FVRFGKRAQT FVRFGKRGQT FVRFGRSAPF EQ
 
 
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