FLP16_CAEEL
ID FLP16_CAEEL Reviewed; 92 AA.
AC Q7YX32;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=FMRFamide-like neuropeptides 16;
DE Contains:
DE RecName: Full=AQTFVRF-amide 1;
DE Contains:
DE RecName: Full=AQTFVRF-amide 2;
DE Contains:
DE RecName: Full=GQTFVRF-amide;
DE Flags: Precursor;
GN Name=flp-16 {ECO:0000312|EMBL:CAE17795.1}; ORFNames=F15D4.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000312|EMBL:CAE17795.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:CAE17795.1};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 58-64; 68-74 AND 78-84, AND AMIDATION AT PHE-64; PHE-74
RP AND PHE-84.
RC STRAIN=Bristol N2 {ECO:0000269|PubMed:16061202};
RX PubMed=16061202; DOI=10.1016/j.bbrc.2005.07.044;
RA Husson S.J., Clynen E., Baggerman G., De Loof A., Schoofs L.;
RT "Discovering neuropeptides in Caenorhabditis elegans by two dimensional
RT liquid chromatography and mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 335:76-86(2005).
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=16187307; DOI=10.1002/neu.20201;
RA Papaioannou S., Marsden D., Franks C.J., Walker R.J., Holden-Dye L.;
RT "Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous
RT system of Caenorhabditis elegans.";
RL J. Neurobiol. 65:304-319(2005).
CC -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic
CC muscle system. {ECO:0000269|PubMed:16187307}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Each flp gene is expressed in a distinct set of
CC neurons. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000255}.
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DR EMBL; Z80344; CAE17795.1; -; Genomic_DNA.
DR RefSeq; NP_001022091.1; NM_001026920.4.
DR AlphaFoldDB; Q7YX32; -.
DR STRING; 6239.F15D4.8; -.
DR PaxDb; Q7YX32; -.
DR EnsemblMetazoa; F15D4.8.1; F15D4.8.1; WBGene00001459.
DR GeneID; 174967; -.
DR UCSC; F15D4.8; c. elegans.
DR CTD; 174967; -.
DR WormBase; F15D4.8; CE34815; WBGene00001459; flp-16.
DR eggNOG; ENOG502TI12; Eukaryota.
DR HOGENOM; CLU_2456864_0_0_1; -.
DR InParanoid; Q7YX32; -.
DR OMA; VDYASQY; -.
DR OrthoDB; 1584688at2759; -.
DR PRO; PR:Q7YX32; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00001459; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
DR GO; GO:0071244; P:cellular response to carbon dioxide; IMP:UniProtKB.
DR GO; GO:1903745; P:negative regulation of pharyngeal pumping; IMP:UniProtKB.
DR GO; GO:0045988; P:negative regulation of striated muscle contraction; IDA:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; TAS:UniProtKB.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..55
FT /evidence="ECO:0000255"
FT /id="PRO_0000312075"
FT PEPTIDE 58..64
FT /note="AQTFVRF-amide 1"
FT /evidence="ECO:0000269|PubMed:16061202"
FT /id="PRO_0000312076"
FT PEPTIDE 68..74
FT /note="AQTFVRF-amide 2"
FT /evidence="ECO:0000269|PubMed:16061202"
FT /id="PRO_0000312077"
FT PEPTIDE 78..84
FT /note="GQTFVRF-amide"
FT /evidence="ECO:0000269|PubMed:16061202"
FT /id="PRO_0000312078"
FT PROPEP 87..92
FT /evidence="ECO:0000255"
FT /id="PRO_0000312079"
FT MOD_RES 64
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16061202"
FT MOD_RES 74
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16061202"
FT MOD_RES 84
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16061202"
SQ SEQUENCE 92 AA; 10270 MW; 7DAE850F89E539E9 CRC64;
MNFSGFEFSS IVAFFLLILQ LSTAAVLPAD YAYGVADEMS ALPDSGSLFA EQRPSKRAQT
FVRFGKRAQT FVRFGKRGQT FVRFGRSAPF EQ