ID   FLP19_CAEEL             Reviewed;          89 AA.
AC   Q9XVX1;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=FMRFamide-like neuropeptides 19;
DE   Contains:
DE     RecName: Full=WANQVRF-amide;
DE   Flags: Precursor;
GN   Name=flp-19 {ECO:0000312|EMBL:CAA90690.1}; ORFNames=M79.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1] {ECO:0000312|EMBL:CAA90690.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|EMBL:CAA90690.1};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 70-76, AND AMIDATION AT PHE-76.
RC   STRAIN=Bristol N2 {ECO:0000269|PubMed:16061202};
RX   PubMed=16061202; DOI=10.1016/j.bbrc.2005.07.044;
RA   Husson S.J., Clynen E., Baggerman G., De Loof A., Schoofs L.;
RT   "Discovering neuropeptides in Caenorhabditis elegans by two dimensional
RT   liquid chromatography and mass spectrometry.";
RL   Biochem. Biophys. Res. Commun. 335:76-86(2005).
RN   [3] {ECO:0000305}
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15236235; DOI=10.1002/cne.20189;
RA   Kim K., Li C.;
RT   "Expression and regulation of an FMRFamide-related neuropeptide gene family
RT   in Caenorhabditis elegans.";
RL   J. Comp. Neurol. 475:540-550(2004).
RN   [4] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=16187307; DOI=10.1002/neu.20201;
RA   Papaioannou S., Marsden D., Franks C.J., Walker R.J., Holden-Dye L.;
RT   "Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous
RT   system of Caenorhabditis elegans.";
RL   J. Neurobiol. 65:304-319(2005).
CC   -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC       WANQVRF-amide inhibits the activity of dissected pharyngeal myogenic
CC       muscle system. {ECO:0000269|PubMed:16187307}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Each flp gene is expressed in a distinct set of
CC       neurons. Flp-19 is expressed in the URX interneurons, the serotonin and
CC       acetylcholine-expressing HSN neurons, and the AIN, AWA and BAG neurons.
CC       {ECO:0000269|PubMed:15236235}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from the comma stage of embryogenesis,
CC       during all larval stages, and in adults. {ECO:0000269|PubMed:15236235}.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000269|PubMed:16061202}.
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DR   EMBL; Z50806; CAA90690.1; -; Genomic_DNA.
DR   PIR; T23831; T23831.
DR   RefSeq; NP_509776.1; NM_077375.4.
DR   AlphaFoldDB; Q9XVX1; -.
DR   SMR; Q9XVX1; -.
DR   BioGRID; 46172; 1.
DR   DIP; DIP-26330N; -.
DR   STRING; 6239.M79.4; -.
DR   PaxDb; Q9XVX1; -.
DR   EnsemblMetazoa; M79.4.1; M79.4.1; WBGene00001462.
DR   GeneID; 181260; -.
DR   KEGG; cel:CELE_M79.4; -.
DR   UCSC; M79.4; c. elegans.
DR   CTD; 181260; -.
DR   WormBase; M79.4; CE18890; WBGene00001462; flp-19.
DR   eggNOG; ENOG502TIAY; Eukaryota.
DR   HOGENOM; CLU_2442938_0_0_1; -.
DR   InParanoid; Q9XVX1; -.
DR   OMA; VVGQPIQ; -.
DR   OrthoDB; 1603783at2759; -.
DR   PRO; PR:Q9XVX1; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00001462; Expressed in larva and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..67
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000312080"
FT   PEPTIDE         70..76
FT                   /note="WANQVRF-amide"
FT                   /evidence="ECO:0000269|PubMed:16061202"
FT                   /id="PRO_0000312081"
FT   PROPEP          80..89
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000312082"
FT   MOD_RES         76
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:16061202"
SQ   SEQUENCE   89 AA;  10095 MW;  5C07CFD0F0E91CF0 CRC64;
     MSFQLTLFSM LFLLIAVVVG QPIQSQNGDL KMQAVQDNSP LNMEAFNDDS ALYDYLEQSD
     PSLKSMEKRW ANQVRFGKRA SWASSVRFG