FLP22_CAEEL
ID FLP22_CAEEL Reviewed; 93 AA.
AC Q93702;
DT 20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=FMRFamide-like neuropeptides 22 {ECO:0000305};
DE Contains:
DE RecName: Full=SPSAKWMRF-amide 1 {ECO:0000305|PubMed:16377032};
DE Contains:
DE RecName: Full=SPSAKWMRF-amide 2 {ECO:0000305|PubMed:16377032};
DE Contains:
DE RecName: Full=SPSAKWMRF-amide 3 {ECO:0000305|PubMed:16377032};
DE Flags: Precursor;
GN Name=flp-22 {ECO:0000312|WormBase:F39H2.1};
GN ORFNames=F39H2.1 {ECO:0000312|WormBase:F39H2.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 47-55; 59-67 AND 71-79, AND MASS SPECTROMETRY.
RX PubMed=28847365; DOI=10.7554/elife.28877;
RA Ohno H., Yoshida M., Sato T., Kato J., Miyazato M., Kojima M., Ida T.,
RA Iino Y.;
RT "Luqin-like RYamide peptides regulate food-evoked responses in C.
RT elegans.";
RL Elife 6:0-0(2017).
RN [3] {ECO:0000305}
RP FUNCTION, AND AMIDATION AT PHE-55; PHE-67 AND PHE-79.
RX PubMed=16377032; DOI=10.1016/j.peptides.2005.11.017;
RA Mertens I., Clinckspoor I., Janssen T., Nachman R., Schoofs L.;
RT "FMRFamide related peptide ligands activate the Caenorhabditis elegans
RT orphan GPCR Y59H11AL.1.";
RL Peptides 27:1291-1296(2006).
CC -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC {ECO:0000305}.
CC -!- FUNCTION: SPSAKWMRF-amide: Acts as a ligand for the npr-22 receptor in
CC vitro. {ECO:0000269|PubMed:16377032}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- MASS SPECTROMETRY: [SPSAKWMRF-amide 1]: Mass=1108.33; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:28847365};
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000255}.
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DR EMBL; BX284601; CAB03086.2; -; Genomic_DNA.
DR PIR; T22006; T22006.
DR RefSeq; NP_492344.2; NM_059943.6.
DR AlphaFoldDB; Q93702; -.
DR STRING; 6239.F39H2.1.2; -.
DR PaxDb; Q93702; -.
DR EnsemblMetazoa; F39H2.1.1; F39H2.1.1; WBGene00009562.
DR GeneID; 172665; -.
DR KEGG; cel:CELE_F39H2.1; -.
DR UCSC; F39H2.1; c. elegans.
DR CTD; 172665; -.
DR WormBase; F39H2.1; CE30530; WBGene00009562; flp-22.
DR eggNOG; ENOG502T0D2; Eukaryota.
DR HOGENOM; CLU_188608_0_0_1; -.
DR InParanoid; Q93702; -.
DR OMA; MNRSVIC; -.
DR OrthoDB; 1644370at2759; -.
DR PRO; PR:Q93702; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00009562; Expressed in larva and 4 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0071855; F:neuropeptide receptor binding; IDA:WormBase.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:WormBase.
DR InterPro; IPR002544; FMRFamid-related_peptide-like.
DR Pfam; PF01581; FARP; 3.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..46
FT /evidence="ECO:0000305"
FT /id="PRO_0000442495"
FT PEPTIDE 47..55
FT /note="SPSAKWMRF-amide 1"
FT /evidence="ECO:0000305|PubMed:16377032"
FT /id="PRO_0000442496"
FT PEPTIDE 59..67
FT /note="SPSAKWMRF-amide 2"
FT /evidence="ECO:0000305|PubMed:16377032"
FT /id="PRO_0000442497"
FT PEPTIDE 71..79
FT /note="SPSAKWMRF-amide 3"
FT /evidence="ECO:0000305|PubMed:16377032"
FT /id="PRO_0000442498"
FT PROPEP 83..93
FT /evidence="ECO:0000305"
FT /id="PRO_0000442499"
FT MOD_RES 55
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000305|PubMed:16377032"
FT MOD_RES 67
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000305|PubMed:16377032"
FT MOD_RES 79
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000305|PubMed:16377032"
SQ SEQUENCE 93 AA; 10585 MW; 5D6BB2346F3B0BFC CRC64;
MNRSMIALCV VLMVSLVSAQ VFDLDGQQLA GLEQNDARLM EQQVKRSPSA KWMRFGKRSP
SAKWMRFGKR SPSAKWMRFG KRSGAEAVSE QDY
