FLP23_CAEEL
ID FLP23_CAEEL Reviewed; 83 AA.
AC P34405; Q4VGN0;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 3.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=FMRFamide-like neuropeptide 23;
DE Contains:
DE RecName: Full=VVGQQDFLRF-amide;
DE Flags: Precursor;
GN Name=flp-23; ORFNames=F22B7.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bristol N2;
RX PubMed=16076468; DOI=10.1016/j.ijpara.2005.05.010;
RA McVeigh P., Leech S., Mair G.R., Marks N.J., Geary T.G., Maule A.G.;
RT "Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.";
RL Int. J. Parasitol. 35:1043-1060(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP IDENTIFICATION.
RX PubMed=15236235; DOI=10.1002/cne.20189;
RA Kim K., Li C.;
RT "Expression and regulation of an FMRFamide-related neuropeptide gene family
RT in Caenorhabditis elegans.";
RL J. Comp. Neurol. 475:540-550(2004).
RN [5]
RP FUNCTION.
RX PubMed=16187307; DOI=10.1002/neu.20201;
RA Papaioannou S., Marsden D., Franks C.J., Walker R.J., Holden-Dye L.;
RT "Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous
RT system of Caenorhabditis elegans.";
RL J. Neurobiol. 65:304-319(2005).
CC -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC {ECO:0000269|PubMed:16187307}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Each flp gene is expressed in a distinct set of
CC neurons.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000305}.
CC -!- CAUTION: The protein was originally predicted to include a TKFQDFLRF-
CC amide peptide, although TKFQDFLRF-amide has no effect on the activity
CC of dissected pharyngeal myogenic muscle system.
CC {ECO:0000305|PubMed:16187307}.
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DR EMBL; AY941160; AAY18633.1; -; mRNA.
DR EMBL; FO080222; CCD62141.2; -; Genomic_DNA.
DR PIR; S44631; S44631.
DR RefSeq; NP_498907.3; NM_066506.4.
DR AlphaFoldDB; P34405; -.
DR PaxDb; P34405; -.
DR EnsemblMetazoa; F22B7.2a.1; F22B7.2a.1; WBGene00017693.
DR GeneID; 184812; -.
DR UCSC; F22B7.2; c. elegans.
DR CTD; 184812; -.
DR WormBase; F22B7.2a; CE47863; WBGene00017693; flp-23.
DR eggNOG; ENOG502TI03; Eukaryota.
DR HOGENOM; CLU_2544644_0_0_1; -.
DR InParanoid; P34405; -.
DR PRO; PR:P34405; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00017693; Expressed in multicellular organism and 1 other tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Amidation; Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..36
FT /evidence="ECO:0000255"
FT /id="PRO_0000372330"
FT PEPTIDE 38..47
FT /note="VVGQQDFLRF-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000372331"
FT PROPEP 50..83
FT /evidence="ECO:0000255"
FT /id="PRO_0000372332"
FT MOD_RES 47
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 83 AA; 8938 MW; 2BD004BB6074361D CRC64;
MLLPKISILL YILVVLQETA AVRGALFRSG RAVPFERVVG QQDFLRFGRA GMASGVGGGS
EGGPDDVKNS YIRVNGEPEI VYQ
