FLP24_CAEEL
ID FLP24_CAEEL Reviewed; 69 AA.
AC O17058; Q5ENY7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 3.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=FMRFamide-like neuropeptides 24;
DE Contains:
DE RecName: Full=VPSAGDMMVRF-amide;
DE Flags: Precursor;
GN Name=flp-24 {ECO:0000312|WormBase:C24A1.1}; ORFNames=C24A1.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000312|EMBL:AAW78866.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:AAW78866.1};
RA McVeigh P., Marks N.J., Maule A.G.;
RT "Characterization of flp-24 homologs in Ascaris suum and Caenorhabditis
RT elegans.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 54-64, AND AMIDATION AT PHE-64.
RC STRAIN=Bristol N2 {ECO:0000269|PubMed:16061202};
RX PubMed=16061202; DOI=10.1016/j.bbrc.2005.07.044;
RA Husson S.J., Clynen E., Baggerman G., De Loof A., Schoofs L.;
RT "Discovering neuropeptides in Caenorhabditis elegans by two dimensional
RT liquid chromatography and mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 335:76-86(2005).
RN [4]
RP IDENTIFICATION.
RX PubMed=16076468; DOI=10.1016/j.ijpara.2005.05.010;
RA McVeigh P., Leech S., Mair G.R., Marks N.J., Geary T.G., Maule A.G.;
RT "Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.";
RL Int. J. Parasitol. 35:1043-1060(2005).
RN [5] {ECO:0000305}
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=27546573; DOI=10.1016/j.cub.2016.07.048;
RA Nath R.D., Chow E.S., Wang H., Schwarz E.M., Sternberg P.W.;
RT "C. elegans Stress-Induced Sleep Emerges from the Collective Action of
RT Multiple Neuropeptides.";
RL Curr. Biol. 26:2446-2455(2016).
CC -!- FUNCTION: Probable FMRFamide-like neuropeptides (PubMed:27546573).
CC Plays a role in behaviors associated with a sleep-like state induced by
CC stress (SIS), acting in concert with the FMRFamide related peptide flp-
CC 13 and neuropeptide-like protein nlp-8 (PubMed:27546573).
CC {ECO:0000269|PubMed:27546573}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the ALA neuron in L4 stage larvae.
CC {ECO:0000269|PubMed:27546573}.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000269|PubMed:16061202}.
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DR EMBL; AY821517; AAW78866.1; -; mRNA.
DR EMBL; FO080637; CCD65361.1; -; Genomic_DNA.
DR PIR; T32261; T32261.
DR RefSeq; NP_497243.3; NM_064842.6.
DR AlphaFoldDB; O17058; -.
DR STRING; 6239.C24A1.1; -.
DR EPD; O17058; -.
DR PaxDb; O17058; -.
DR EnsemblMetazoa; C24A1.1.1; C24A1.1.1; WBGene00016028.
DR GeneID; 182824; -.
DR KEGG; cel:CELE_C24A1.1; -.
DR UCSC; C24A1.1.1; c. elegans.
DR CTD; 182824; -.
DR WormBase; C24A1.1; CE38488; WBGene00016028; flp-24.
DR eggNOG; KOG3216; Eukaryota.
DR HOGENOM; CLU_2833461_0_0_1; -.
DR InParanoid; O17058; -.
DR OMA; AQWGEIP; -.
DR OrthoDB; 1625763at2759; -.
DR PRO; PR:O17058; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00016028; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..51
FT /evidence="ECO:0000255"
FT /id="PRO_0000312083"
FT PEPTIDE 54..64
FT /note="VPSAGDMMVRF-amide"
FT /evidence="ECO:0000269|PubMed:16061202"
FT /id="PRO_0000312084"
FT PROPEP 68..69
FT /evidence="ECO:0000255"
FT /id="PRO_0000312085"
FT MOD_RES 64
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16061202"
SQ SEQUENCE 69 AA; 7769 MW; AE5F89FB31D8581F CRC64;
MLSSRTSSII LILAILVAIM AVAQCRNIQY DVEEMTPEAA FRYAQWGEIP HKRVPSAGDM
MVRFGKRSI
