FLP26_CAEEL
ID FLP26_CAEEL Reviewed; 84 AA.
AC Q8MPY9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=FMRFamide-like neuropeptides 26;
DE Contains:
DE RecName: Full=EFNADDLTLRF-amide;
DE Contains:
DE RecName: Full=GGAGEPLAFSPDMLSLRF-amide;
DE Flags: Precursor;
GN Name=flp-26 {ECO:0000312|WormBase:R173.4}; ORFNames=R173.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 51-61 AND 65-82, AND AMIDATION AT PHE-61 AND PHE-82.
RC STRAIN=Bristol N2 {ECO:0000269|PubMed:16061202};
RX PubMed=16061202; DOI=10.1016/j.bbrc.2005.07.044;
RA Husson S.J., Clynen E., Baggerman G., De Loof A., Schoofs L.;
RT "Discovering neuropeptides in Caenorhabditis elegans by two dimensional
RT liquid chromatography and mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 335:76-86(2005).
CC -!- FUNCTION: FMRFamides and FMRFamide-like peptides are neuropeptides.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Each flp gene is expressed in a distinct set of
CC neurons. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000269|PubMed:16061202}.
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DR EMBL; FO080190; CCD61850.1; -; Genomic_DNA.
DR RefSeq; NP_741827.1; NM_171717.5.
DR AlphaFoldDB; Q8MPY9; -.
DR STRING; 6239.R173.4; -.
DR EPD; Q8MPY9; -.
DR PaxDb; Q8MPY9; -.
DR EnsemblMetazoa; R173.4.1; R173.4.1; WBGene00020126.
DR GeneID; 259712; -.
DR KEGG; cel:CELE_R173.4; -.
DR UCSC; R173.4; c. elegans.
DR CTD; 259712; -.
DR WormBase; R173.4; CE31059; WBGene00020126; flp-26.
DR eggNOG; ENOG502R8X3; Eukaryota.
DR HOGENOM; CLU_2560417_0_0_1; -.
DR InParanoid; Q8MPY9; -.
DR OMA; YESKPYK; -.
DR OrthoDB; 1796618at2759; -.
DR PRO; PR:Q8MPY9; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00020126; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..48
FT /evidence="ECO:0000255"
FT /id="PRO_0000312086"
FT PEPTIDE 51..61
FT /note="EFNADDLTLRF-amide"
FT /evidence="ECO:0000269|PubMed:16061202"
FT /id="PRO_0000312087"
FT PEPTIDE 65..82
FT /note="GGAGEPLAFSPDMLSLRF-amide"
FT /evidence="ECO:0000269|PubMed:16061202"
FT /id="PRO_0000312088"
FT MOD_RES 61
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16061202"
FT MOD_RES 82
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16061202"
SQ SEQUENCE 84 AA; 9560 MW; A7AC08F35BF1A1C4 CRC64;
MKVMFMLALL FSSLVATSAF RLPFQFFGAN EDFNSGLTKR NYYESKPYKR EFNADDLTLR
FGKRGGAGEP LAFSPDMLSL RFGK
